The sensing enterprise is a digital business innovation concept making Cyber-Physical Systems, service-oriented architectures and advanced human-computer interactions converge, supporting a more agile, flexible, and proactive management of unexpected events in today’s global value networks. In essence, it concerns the adoption of future Internet technologies in virtual enterprises. Translating this concept to a general approach to smart systems (smart manufacturing, smart cities, smart logistics, etc.), requires new capabilities by next-generation information systems to perform sensing, modelling, and interpretation of “any” signal from the real world, thus providing the systems with higher flexibility and possibilities for reconfiguration (Panetto et al. 2016). Intuitively, a sensing system requires resources and machineries to be constantly monitored, configured, and easily controlled by human operators. All these functions, and much more indeed, are now implemented by the so-called (Industrial) Internet of Things or Cyber-Physical Systems. With the advent of the new cyber-physical system design paradigm, the number and diversity of systems that need to work together in the future enterprises have significantly increased (Weichhart et al. 2016). This trend highlights the need to shift from the classic central control of systems, towards systems interoperability as a capability to control, sense, and perceive distributed and heterogeneous systems and their environments, as well as to purposefully and socially act upon their perceptions. Such a shift could have important consequences on the future architecture design of the control of these systems. The emergence of cloud-based technologies will also have a significant impact on the design and implementation of cyber-physical systems; using such novel technologies, collaborative engineering practises will increase globally, thus enabling a new generation of small-scale industrial organizations to function in an information-centric manner and enabling industry 4.0 transformations (Cimini, et al, 2017). The potential of such technologies in fostering a leaner and more agile approach towards engineering is very high. Engineers and engineering organizations no longer have to be restricted to the availability of advanced processing capabilities, as they can adopt a ‘pay as you go’ approach, which will enable them to access and use software resources for engineering activities from any remote location in the world.