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Communication Dans Un Congrès Année : 2018

Role of HIF-1α in the migration/invasion processes in response to photon and C-ion irradiations

Résumé

Purpose: The survival rate of patients with HNSCC remains low due to recurrences. Metastasis, but also cancer stem cells (CSC), located in hypoxic niches, play a key role in these relapses. HIF-1α protein (Hypoxia Inducible Factor 1α), stabilized by hypoxia and radical species induced by ionizing radiations, is involved in the radio-resistance to photons but also in the epithelial mesenchymal transition (EMT). The understanding of the differential molecular mechanisms HIF-1α-dependent involved in the EMT and induced by photons and C-ion radiations must be deepened under normoxic conditions and particularly under hypoxia in CSCs, especially since hypoxia constitutes a tumor microenvironment promoting metastases and CSCs.
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Dates et versions

hal-02064756 , version 1 (12-03-2019)

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  • HAL Id : hal-02064756 , version 1

Citer

Anne-Sophie Wozny, Guillaume Vares, Tetsuo Nakajima, Akira Fujimori, Michael Beuve, et al.. Role of HIF-1α in the migration/invasion processes in response to photon and C-ion irradiations. ESTRO 37 - Innovation for Value and Access, Apr 2018, Barcelona, Spain. ⟨hal-02064756⟩
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