Persistent Organic Pollutant Exposure Leads to Insulin Resistance Syndrome
Jérôme Ruzzin
(1)
,
Rasmus K. Petersen
(2)
,
Emmanuelle Fouilloux-Meugnier
(3)
,
Lise Madsen
(4)
,
Erik-Jan Lock
(1)
,
Haldis Lillefosse
(1)
,
Tao Ma
(5)
,
Sandra Pesenti
(3)
,
Si Brask Sonne
(6)
,
Troels Torben Ma
(6)
,
Marian Kjellevold Malde
(1)
,
Zhen-Yu Du
(7)
,
Carine Chavey
(8)
,
Lluis Fajas
(8)
,
Anne-Katrine Lundebye
(1)
,
Christian Lehn Brand
(9)
,
Hubert Vidal
(3)
,
Karsten Kristiansen
(10)
,
Livar Frøyland
(1)
1
NIFES -
National Institute of Nutrition and Seafood Research
2 Department of Biochemistry and Molecular Biology
3 CarMeN - Cardiovasculaire, métabolisme, diabétologie et nutrition
4 Laboratory of Genomics and Molecular Biomedicine, Department of Biology
5 SRL - Simula Research Laboratory [Lysaker]
6 Department of Biology [Copenhagen]
7 Laboratory of Aquaculture Nutrition and Environmental Health (LANEH)
8 IRCM - U896 Inserm - UM1 - Institut de recherche en cancérologie de Montpellier
9 CBMR - Novo Nordisk Foundation Center for Basic Metabolic Research
10 UCPH - University of Copenhagen = Københavns Universitet
2 Department of Biochemistry and Molecular Biology
3 CarMeN - Cardiovasculaire, métabolisme, diabétologie et nutrition
4 Laboratory of Genomics and Molecular Biomedicine, Department of Biology
5 SRL - Simula Research Laboratory [Lysaker]
6 Department of Biology [Copenhagen]
7 Laboratory of Aquaculture Nutrition and Environmental Health (LANEH)
8 IRCM - U896 Inserm - UM1 - Institut de recherche en cancérologie de Montpellier
9 CBMR - Novo Nordisk Foundation Center for Basic Metabolic Research
10 UCPH - University of Copenhagen = Københavns Universitet
Emmanuelle Fouilloux-Meugnier
- Fonction : Auteur
- PersonId : 171473
- IdHAL : emmanuelle-meugnier
- ORCID : 0000-0002-2291-7691
- IdRef : 253124204
Lise Madsen
- Fonction : Auteur
- PersonId : 767375
- ORCID : 0000-0001-6108-1236
Sandra Pesenti
- Fonction : Auteur
- PersonId : 747905
- IdHAL : sandra-pesenti
- ORCID : 0000-0003-4037-208X
Carine Chavey
- Fonction : Auteur
- PersonId : 180766
- IdHAL : carine-chavey
- ORCID : 0000-0002-5267-5638
Lluis Fajas
- Fonction : Auteur
- PersonId : 863450
Hubert Vidal
- Fonction : Auteur
- PersonId : 21591
- IdHAL : hubert-vidal
- ORCID : 0000-0002-9467-0317
- IdRef : 034238875
Karsten Kristiansen
- Fonction : Auteur
- PersonId : 960804
Résumé
Background: the incidence of the insulin resistance syndrome has increased at an alarming rate worldwide, creating a serious challenge to public health care in the 21st century. Recently, epide-miological studies have associated the prevalence of type 2 diabetes with elevated body burdens of persistent organic pollutants (POPs). However, experimental evidence demonstrating a causal link between POPs and the development of insulin resistance is lacking. Objective: We investigated whether exposure to POPs contributes to insulin resistance and meta-bolic disorders. Methods: Sprague-Dawley rats were exposed for 28 days to lipophilic POPs through the con-sumption of a high-fat diet containing either refined or crude fish oil obtained from farmed Atlantic salmon. In addition, differentiated adipocytes were exposed to several POP mixtures that mimicked the relative abundance of organic pollutants present in crude salmon oil. We measured body weight, whole-body insulin sensitivity, POP accumulation, lipid and glucose homeostasis, and gene expres-sion and we performed micro array analysis. Results: Adult male rats exposed to crude, but not refined, salmon oil developed insulin resis-tance, abdominal obesity, and hepatosteatosis. The contribution of POPs to insulin resistance was confirmed in cultured adipocytes where POPs, especially organochlorine pesticides, led to robust inhibition of insulin action. Moreover, POPs induced down-regulation of insulin-induced gene-1 (Insig-1) and Lpin1, two master regulators of lipid homeostasis. Conclusion: Our findings provide evidence that exposure to POPs commonly present in food chains leads to insulin resistance and associated metabolic disorders
Format du dépôt | Fichier |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
Persistent Organic Pollutant Exposure Leads to Insulin Resistance Syndrome
|
Résumé |
en
Background: the incidence of the insulin resistance syndrome has increased at an alarming rate worldwide, creating a serious challenge to public health care in the 21st century. Recently, epide-miological studies have associated the prevalence of type 2 diabetes with elevated body burdens of persistent organic pollutants (POPs). However, experimental evidence demonstrating a causal link between POPs and the development of insulin resistance is lacking. Objective: We investigated whether exposure to POPs contributes to insulin resistance and meta-bolic disorders. Methods: Sprague-Dawley rats were exposed for 28 days to lipophilic POPs through the con-sumption of a high-fat diet containing either refined or crude fish oil obtained from farmed Atlantic salmon. In addition, differentiated adipocytes were exposed to several POP mixtures that mimicked the relative abundance of organic pollutants present in crude salmon oil. We measured body weight, whole-body insulin sensitivity, POP accumulation, lipid and glucose homeostasis, and gene expres-sion and we performed micro array analysis. Results: Adult male rats exposed to crude, but not refined, salmon oil developed insulin resis-tance, abdominal obesity, and hepatosteatosis. The contribution of POPs to insulin resistance was confirmed in cultured adipocytes where POPs, especially organochlorine pesticides, led to robust inhibition of insulin action. Moreover, POPs induced down-regulation of insulin-induced gene-1 (Insig-1) and Lpin1, two master regulators of lipid homeostasis. Conclusion: Our findings provide evidence that exposure to POPs commonly present in food chains leads to insulin resistance and associated metabolic disorders
|
Auteur(s) |
Jérôme Ruzzin
1
, Rasmus K. Petersen
2
, Emmanuelle Fouilloux-Meugnier
3
, Lise Madsen
4
, Erik-Jan Lock
1
, Haldis Lillefosse
1
, Tao Ma
5
, Sandra Pesenti
3
, Si Brask Sonne
6
, Troels Torben Ma
6
, Marian Kjellevold Malde
1
, Zhen-Yu Du
7
, Carine Chavey
8
, Lluis Fajas
8
, Anne-Katrine Lundebye
1
, Christian Lehn Brand
9
, Hubert Vidal
3
, Karsten Kristiansen
10
, Livar Frøyland
1
1
NIFES -
National Institute of Nutrition and Seafood Research
( 430963 )
- Norvège
2
Department of Biochemistry and Molecular Biology
( 100592 )
- Odense
- Danemark
3
CarMeN -
Cardiovasculaire, métabolisme, diabétologie et nutrition
( 139835 )
- Faculté de Médecine Lyon Sud - BP 12 - 165 Chemin du Grand Revoyet - 69921 Oullins cedex INSA, Bât. IMBL, La Doua - 11 Avenue Jean Capelle - 69621 Villeurbanne Cedex
- France
4
Laboratory of Genomics and Molecular Biomedicine, Department of Biology
( 430961 )
- Danemark
5
SRL -
Simula Research Laboratory [Lysaker]
( 23364 )
- Leon Moonen
Simula Research Laboratory
P.O. Box 134
1325 Lysaker
Norway
- Norvège
6
Department of Biology [Copenhagen]
( 522127 )
- Copenhagen Biocenter, Ole Maaløes Vej 5, DK-2200 Copenhagen N
- Danemark
7
Laboratory of Aquaculture Nutrition and Environmental Health (LANEH)
( 510210 )
- Chine
8
IRCM - U896 Inserm - UM1 -
Institut de recherche en cancérologie de Montpellier
( 55685 )
- 208 rue des Apothicaires F-34298 Montpellier
- France
9
CBMR -
Novo Nordisk Foundation Center for Basic Metabolic Research
( 226376 )
- Blegdamsvej 3B, Building 7 (Maersk Tower)
DK-2200 Copenhagen N
- Danemark
10
UCPH -
University of Copenhagen = Københavns Universitet
( 460939 )
- Nørregade 10, 1165 København, Danemark
- Danemark
|
Langue du document |
Anglais
|
Nom de la revue |
|
Vulgarisation |
Non
|
Comité de lecture |
Oui
|
Audience |
Internationale
|
Date de publication |
2010-04
|
Volume |
118
|
Numéro |
4
|
Page/Identifiant |
465-471
|
Domaine(s) |
|
Mots-clés |
en
Contaminants, farmed salmon, metabolic syndrome, nonalcoholic fatty liver, obesity, pollution, public health, type 2 diabetes
|
DOI | 10.1289/ehp.0901321 |
Origine :
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