An extension of the large eddy simulation (LES) technique to two-phase reacting flows, required to capture and predict the behavior of industrial burners, is presented. While most efforts reported in the literature to construct LES solvers for two-phase flow focus on Euler–Lagrange formulation, the present work explores a different solution (‘two-fluid’ approach) where an Eulerian formulation is used for the liquid phase and coupled with the LES solver of the gas phase. The equations used for each phase and the coupling terms are presented before describing validation in two simple cases which gather some of the specificities of real combustion chamber: (1) a one-dimensional laminar JP10/air flame and (2) a non-reacting swirled flow where solid particles disperse (Sommerfeld and Qiu, Int. J. Multiphase Flow 19(6):1093–1127, 1993). After these validations, the LES tool is applied to a realistic aircraft combustion chamber to study both a steady flame regime and an ignition sequence by a spark. Results bring new insights into the physics of these complex flames and demonstrate the capabilities of two-fluid LES.