This paper is motivated by the optimization of so-called lattice materials which are becoming increasingly popular in the context of additive manufacturing. Generalizing our previous work in 2-d we propose a method for topology optimization of structures made of periodically perforated material , where the microscopic periodic cell can be macroscopically modulated and oriented. This method is made of three steps. The first step amounts to compute the homogenized properties of an adequately chosen parametrized mi-crostructure (here, a cubic lattice with varying bar thicknesses). The second step optimizes the homogenized formulation of the problem, which is a classical problem of parametric optimization. The third, and most delicate, step projects the optimal oriented microstructure at a desired length scale. Compared to the 2-d case where rotations are parametrized by a single angle, to which a confor-mality constraint can be applied, the 3-d case is more involved and requires new ingredients. In particular, the full rotation matrix is regularized (instead of just one angle in 2-d) and the projection map which deforms the square periodic lattice is computed component by component. Several numerical examples are presented for compliance minimization in 3-d.