Lipid profile and cardiovascular risk factors in pediatric liver transplant recipients
E. Roblin
,
J. Dumortier
,
Mathilde Di Filippo
(1)
,
S. Collardeau-Frachon
,
Agnès Sassolas
(1)
,
N. Peretti
,
A. Serusclat
,
C. Rivet
,
O. Boillot
,
A. Lachaux
E. Roblin
- Fonction : Auteur
J. Dumortier
- Fonction : Auteur
- PersonId : 762386
- ORCID : 0000-0002-7824-5396
- IdRef : 07665933X
Mathilde Di Filippo
- Fonction : Auteur
- PersonId : 773403
- ORCID : 0000-0001-6206-5908
- IdRef : 175917035
S. Collardeau-Frachon
- Fonction : Auteur
N. Peretti
- Fonction : Auteur
A. Serusclat
- Fonction : Auteur
C. Rivet
- Fonction : Auteur
O. Boillot
- Fonction : Auteur
A. Lachaux
- Fonction : Auteur
- PersonId : 907892
Résumé
Cardiovascular diseases induce long-term morbidity and mortality of adult LT recipients. The aim of this retrospective study was to assess CVRF, lipid abnormalities, and atherosclerosis (appraised by c-IMT), more than 10 yr after pediatric LT. Thirty-one children who underwent LT between December 1990 and December 2000 were included. Median age at LT was 14 months (range 4-64), and median follow-up after LT was 11.9 yr (range 9.0-17.3). In our cohort, obesity (9.7%) and treated hypertension (9.7%) were rare. None of the patients was smoker or diabetic. High TC and TG were both observed in 6.5% of the patients. The mean c-IMT for male patients was 1.22 +/- 1.55 and 1.58 +/- 1.23 mm in female patients. Seven patients (22%) had a mean c-IMT above +2 s.d. Values below the 5th percentile were noted for LDL-cholesterol (58.1%), HDL-cholesterol (25.8%), apolipoprotein B (40%), and apolipoprotein A1 (20%). LDL-cholesterol and apolipoprotein B levels were significantly lower in patients treated by tacrolimus in comparison with CsA (p \textless 0.05). In conclusion, our results suggest that pediatric LT patients do not present significant CVRF; moreover, instead of hyperlipidemia, hypocholesterolemia (LDL-C) is frequent and immunosuppressive therapy is probably the cause.
Domaines
Sciences du Vivant [q-bio]Format du dépôt | Notice |
---|---|
Type de dépôt | Article dans une revue |
Résumé |
en
Cardiovascular diseases induce long-term morbidity and mortality of adult LT recipients. The aim of this retrospective study was to assess CVRF, lipid abnormalities, and atherosclerosis (appraised by c-IMT), more than 10 yr after pediatric LT. Thirty-one children who underwent LT between December 1990 and December 2000 were included. Median age at LT was 14 months (range 4-64), and median follow-up after LT was 11.9 yr (range 9.0-17.3). In our cohort, obesity (9.7%) and treated hypertension (9.7%) were rare. None of the patients was smoker or diabetic. High TC and TG were both observed in 6.5% of the patients. The mean c-IMT for male patients was 1.22 +/- 1.55 and 1.58 +/- 1.23 mm in female patients. Seven patients (22%) had a mean c-IMT above +2 s.d. Values below the 5th percentile were noted for LDL-cholesterol (58.1%), HDL-cholesterol (25.8%), apolipoprotein B (40%), and apolipoprotein A1 (20%). LDL-cholesterol and apolipoprotein B levels were significantly lower in patients treated by tacrolimus in comparison with CsA (p \textless 0.05). In conclusion, our results suggest that pediatric LT patients do not present significant CVRF; moreover, instead of hyperlipidemia, hypocholesterolemia (LDL-C) is frequent and immunosuppressive therapy is probably the cause.
|
Titre |
en
Lipid profile and cardiovascular risk factors in pediatric liver transplant recipients
|
Auteur(s) |
E. Roblin
, J. Dumortier
, Mathilde Di Filippo
1
, S. Collardeau-Frachon
, Agnès Sassolas
1
, N. Peretti
, A. Serusclat
, C. Rivet
, O. Boillot
, A. Lachaux
1
CarMeN -
Cardiovasculaire, métabolisme, diabétologie et nutrition
( 139835 )
- Faculté de Médecine Lyon Sud - BP 12 - 165 Chemin du Grand Revoyet - 69921 Oullins cedex INSA, Bât. IMBL, La Doua - 11 Avenue Jean Capelle - 69621 Villeurbanne Cedex
- France
|
Public visé |
Scientifique
|
Nom de la revue |
|
Sous-type de document pour les Articles |
Research article
|
Langue du document |
Anglais
|
Page/Identifiant |
241-8
|
Date de publication |
2016-03
|
Audience |
Internationale
|
Comité de lecture |
Oui
|
Vulgarisation |
Non
|
Volume |
20
|
Numéro |
2
|
Domaine(s) |
|
Voir aussi |
|
Indexation contrôlée |
|
Mots-clés |
fr
pediatric liver transplantation, outcome
|
DOI | 10.1111/petr.12664 |
ProdINRA | 375274 |
Pubmed Id | 26750745 |
UT key WOS | 000371433100009 |
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