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Article dans une revue Pediatric Transplantation Année : 2016

Lipid profile and cardiovascular risk factors in pediatric liver transplant recipients

E. Roblin
  • Fonction : Auteur
J. Dumortier
S. Collardeau-Frachon
  • Fonction : Auteur
N. Peretti
  • Fonction : Auteur
A. Serusclat
  • Fonction : Auteur
C. Rivet
  • Fonction : Auteur
O. Boillot
  • Fonction : Auteur
A. Lachaux
  • Fonction : Auteur
  • PersonId : 907892

Résumé

Cardiovascular diseases induce long-term morbidity and mortality of adult LT recipients. The aim of this retrospective study was to assess CVRF, lipid abnormalities, and atherosclerosis (appraised by c-IMT), more than 10 yr after pediatric LT. Thirty-one children who underwent LT between December 1990 and December 2000 were included. Median age at LT was 14 months (range 4-64), and median follow-up after LT was 11.9 yr (range 9.0-17.3). In our cohort, obesity (9.7%) and treated hypertension (9.7%) were rare. None of the patients was smoker or diabetic. High TC and TG were both observed in 6.5% of the patients. The mean c-IMT for male patients was 1.22 +/- 1.55 and 1.58 +/- 1.23 mm in female patients. Seven patients (22%) had a mean c-IMT above +2 s.d. Values below the 5th percentile were noted for LDL-cholesterol (58.1%), HDL-cholesterol (25.8%), apolipoprotein B (40%), and apolipoprotein A1 (20%). LDL-cholesterol and apolipoprotein B levels were significantly lower in patients treated by tacrolimus in comparison with CsA (p \textless 0.05). In conclusion, our results suggest that pediatric LT patients do not present significant CVRF; moreover, instead of hyperlipidemia, hypocholesterolemia (LDL-C) is frequent and immunosuppressive therapy is probably the cause.
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Dates et versions

hal-01850350, version 1 (27-07-2018)

Identifiants

Citer

E. Roblin, J. Dumortier, Mathilde Di Filippo, S. Collardeau-Frachon, Agnès Sassolas, et al.. Lipid profile and cardiovascular risk factors in pediatric liver transplant recipients. Pediatric Transplantation, 2016, 20 (2), pp.241-8. ⟨10.1111/petr.12664⟩. ⟨hal-01850350⟩
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