Analysis of Hemodynamic Changes and Bold Signals of Sickle Cell Disease Patients during Desaturation
Résumé
Using nearinfrared spectroscopy (NIRS), previous studies have shown that sicklecell disease (SCD) patients have low cerebral oxygen saturation values. Moreover, the hemoglobin S in sickle cell disease has impaired oxygen carrying capacity. Here, we propose to investigate the effect of induced desaturation on the SCD brain. In particular, we analyzed the falling functional magnetic resonance imaging (fMRI) response during hypoxia, which results from local concentration changes in paramagnetic deoxyhemoglobin (DHB). Moreover, we also explore the nearinfrared spectroscopy (NIRS) changes in oxygenated and deoxygenated hemoglobin from the human prefrontal cortex.
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