Electro-click construction of hybrid nanocapsule films with triggered delivery properties - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Physical Chemistry Chemical Physics Année : 2018

Electro-click construction of hybrid nanocapsule films with triggered delivery properties

Résumé

Hollow nanocapsules (named Hybridosomes®) possessing a polymer/nanoparticle shell were used to covalently construct hybrid films in a one-pot fashion. The alkyne bearing organic/inorganic Hybridosomes® were reticulated with azide bearing homobifunctional polyethyleneglycol (PEG) linkers, by using an electro-click reaction on F-SnO2 (FTO) electrodes. The coatings were obtained by promoting the Cu(i)-catalyzed click reaction between alkyne and azide moieties in the vicinity of the electrode by the electrochemical generation of Cu(i) ions. The physicochemical properties of the covalently reticulated hybrid films obtained were studied by SEM, AFM, UV-vis and fluorescence spectroscopy. The one-pot covalent click reaction between the nanocapsules and the PEG linkers in the film did not affect the desirable features of the Hybridosomes® i.e. their hollow nanostructure their chemical versatility and their pH-sensitivity. Consequently, both the composition and the cargo-loading of the Hybridosomes® films could be tuned, demonstrating the versatility of these hybrid coatings. For example, the Hybridosome® films were used to encapsulate and release a bodipy fluorescent probe in response to either a pH drop or the application of an oxidative +1 V potential (vs. Ag/AgCl) at the substrate. By advancing the field of electro-synthesized films a step further toward the design of complex physicochemical interfaces, these results open perspectives for multifunctional coatings where chemical versatility, controllable stability and a hollow nanostructure are required.
Fichier principal
Vignette du fichier
Sciortino et al_revised.pdf (1.42 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-01684549 , version 1 (11-09-2020)

Identifiants

Citer

Flavien Sciortino, Gaulthier Rydzek, Fabien Grasset, Myrtil L Kahn, Jonathan P Hill, et al.. Electro-click construction of hybrid nanocapsule films with triggered delivery properties. Physical Chemistry Chemical Physics, 2018, 20 (4), pp.2761-2770. ⟨10.1039/c7cp07506e⟩. ⟨hal-01684549⟩
157 Consultations
94 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More