Synthesis of Carbo[6]helicene Derivatives Grafted with Amino or Aminoester Substituents from Enantiopure [6]Helicenyl Boronates
Résumé
Enantiopure carbo[6]helicenyl boronates were synthesized using a photocyclisation reaction as the key step. These compounds were further converted to various amino derivatives using copper-catalyzed azidation or amination and reductive alkylation of benzylazide by a helicenyl dichloroborane. Asymmetric Petasis condensation with glyoxylic acid and morpholine controlled by the helical chirality afforded the corresponding amino esters.
Domaines
Chimie organique
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Synthesis of Carbo[6]Helicene Derivatives_accepted.pdf (1.22 Mo)
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Synthesis of Carbo[6]Helicene Derivatives_supplementary material.pdf (2.91 Mo)
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