It is common accepted that complex systems or cyber-physical systems need co-simulation for their study. Further more, they are made of heterogeneous subsystems that have to exchange data. Usually each subsystem is modeled using specific tools, environments and sim-ulators. The simulators have to interoperate to realize all the simulation of the system. It is known that in-teroperativity is a broad and complex subject. Interop-erability is a strong commitment as the communication solution in heterogeneous systems. This paper describes a co-simulation framework interoperability based FMI (Functional Mock up Interface) standard for the structural part and data mediation for semantic part. We present a case study for Neo-Campus project that shows how the framework helps to build the semantic interop-erability of a cyberphysical system.