NanOx TM : a new multiscale model to predict ion RBE in hadrontherapy
Résumé
Nanox, a new biophysical model developed to predict cell survival probability in the context of hadrontherapy, will be presented in the following. The model takes into account the fully stochastic nature of ionizing radiation by considering dose fuctuations both at nanometric and micrometric scales, and introduces the concept of chemical specific energy. The latter represents the induction of cell death by non-local events as the accumulation of cellular oxidative stress or sub-lethal lesions induced by reactive chemical species. Such non-local events are complementary to local events, which take place at a very localized scale and are considered as lethal since can singly cause cell death. NanOx predictions for V79, CHO-K1 and HSG cell lines irradiated by carbon ions are in good agreement with the experimental data. The model is able to describe the effectiveness of ions, including the overkill effect at high LET values, via the fit of a limited set of parameters. Moreover, the typical shoulder in cell survival curves is reproduced owing to the introduction of the chemical specific energy which varies with LET.
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