This paper will examine the opportunities and the challenges offered by cross- and multi-cultural e-learning. We explore the research on the potential cultural impact of the computer in the classroom, teaching within multicultural classrooms and across cultures. Part of the presentation will also focus on the recent experiences of the eTUTOR team as it has set up and is presently delivering synchronous e-learning across cultures. The project spans five European institutions and each partner is in the process of exploring a range of e-learning environments and delivery styles specifically in relation to multicultural, synchronous and collaborative situations.