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Article Dans Une Revue Journal of Physical Chemistry Letters Année : 2017

Dynamic Nuclear Polarization of Long-Lived Nuclear Spin States in Methyl Groups

Résumé

We have induced hyperpolarized long-lived states in compounds containing C-13-bearing methyl groups by dynamic nuclear polarization (DNP) at cryogenic temperatures, followed by dissolution with a warm solvent. The hyper polarized methyl long-lived states give rise to enhanced antiphase C-13 NMR signals in solution, which often persist for times much longer than the C-13 and H-1 spin-lattice relaxation times under the same conditions. The DNP-induced effects are similar to quantum-rotor-induced polarization (QRIP) but are observed in a wider range of compounds because they do not depend critically on the height of the rotational barrier. We interpret our observations with a model in which nuclear Zeeman and methyl tunnelling reservoirs adopt an approximately uniform temperature, under DNP conditions. The generation of hyperpolarized NMR signals that persist for relatively long times in a range of methyl-bearing substances may be important for applications such as investigations of metabolism, enzymatic reactions, protein ligand binding, drug screening, and molecular imaging.
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Dates et versions

hal-01579368 , version 1 (23-10-2019)

Identifiants

Citer

Jean-Nicolas Dumez, Basile Vuichoud, Daniele Mammoli, Aurélien Bornet, Arthur C. Pinon, et al.. Dynamic Nuclear Polarization of Long-Lived Nuclear Spin States in Methyl Groups. Journal of Physical Chemistry Letters, 2017, 8 (15), pp.3549-3555. ⟨10.1021/acs.jpclett.7b01512⟩. ⟨hal-01579368⟩
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