Formation of DNA-copolymer fibrils through an amyloid-like nucleation polymerization mechanism - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Macromolecular Rapid Communications Année : 2015

Formation of DNA-copolymer fibrils through an amyloid-like nucleation polymerization mechanism

D. Kedracki
  • Fonction : Auteur
S.K. Filippov
  • Fonction : Auteur
N. Gour
  • Fonction : Auteur
H. Schlaad
  • Fonction : Auteur

Résumé

Conjugation of a hydrophobic poly(2-oxazoline) bearing tertiary amide groups along its backbone with a short single stranded nucleotide sequence results in an amphiphilic comb/graft copolymer, which organizes in fibrils upon direct dissolution in water. Supported by circular dichroism, atomic force microscopy, transmission electron microscopy, and scattering data, fibrils are formed through inter- and intramolecular hydrogen bonding between hydrogen accepting amide groups along the polymer backbone and hydrogen donating nucleic acid grafts leading to the formation of hollow tubes. Conjugation of hydrophobic poly(2-oxazoline) bearing tertiary amide groups along its backbone with a short single stranded nucleotide sequence results in an amphiphilic comb/graft copolymer which organizes in fibrils in aqueous solution according to a nucleation polymerization mechanism. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Dates et versions

hal-01564173 , version 1 (18-07-2017)

Identifiants

Citer

D. Kedracki, S.K. Filippov, N. Gour, H. Schlaad, Corinne Nardin. Formation of DNA-copolymer fibrils through an amyloid-like nucleation polymerization mechanism. Macromolecular Rapid Communications, 2015, 36 (8), pp.768-773. ⟨10.1002/marc.201400728⟩. ⟨hal-01564173⟩
19 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More