Formation of DNA-copolymer fibrils through an amyloid-like nucleation polymerization mechanism
Résumé
Conjugation of a hydrophobic poly(2-oxazoline) bearing tertiary amide groups along its backbone with a short single stranded nucleotide sequence results in an amphiphilic comb/graft copolymer, which organizes in fibrils upon direct dissolution in water. Supported by circular dichroism, atomic force microscopy, transmission electron microscopy, and scattering data, fibrils are formed through inter- and intramolecular hydrogen bonding between hydrogen accepting amide groups along the polymer backbone and hydrogen donating nucleic acid grafts leading to the formation of hollow tubes. Conjugation of hydrophobic poly(2-oxazoline) bearing tertiary amide groups along its backbone with a short single stranded nucleotide sequence results in an amphiphilic comb/graft copolymer which organizes in fibrils in aqueous solution according to a nucleation polymerization mechanism. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.