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Article Dans Une Revue Journal of Immunology Année : 2012

Cutting Edge: Neuronal Recognition by CD8 T Cells Elicits Central Diabetes Insipidus

Tanja Scheikl
  • Fonction : Auteur
Beatrice Pignolet
Cecile Dalard
  • Fonction : Auteur
Sabine Desbois
  • Fonction : Auteur
Daniele Raison
  • Fonction : Auteur
Masanori Yamazaki
  • Fonction : Auteur
Abdelhadi Saoudi
Jan Bauer
Hans Lassmann
  • Fonction : Auteur
Roland Liblau

Résumé

An increasing number of neurologic diseases is associated with autoimmunity. The immune effectors contributing to the pathogenesis of such diseases are often unclear. To explore whether self-reactive CD8 T cells could attack CNS neurons in vivo, we generated a mouse model in which the influenza virus hemagglutinin (HA) is expressed specifically in CNS neurons. Transfer of cytotoxic anti-HA CD8 T cells induced an acute but reversible encephalomyelitis in HA-expressing recipient mice. Unexpectedly, diabetes insipidus developed in surviving animals. This robust phenotype was associated with preferential accumulation of cytotoxic CD8 T cells in the hypothalamus, upregulation of MHC class I molecules, and destruction of vasopressin-expressing neurons. IFN-gamma production by the pathogenic CD8 T cells was necessary for MHC class I upregulation by hypothalamic neurons and their destruction. This novel mouse model, in combination with related human data, supports the concept that autoreactive CD8 T cells can trigger central diabetes insipidus. The Journal of Immunology, 2012, 188: 4731-4735.

Dates et versions

hal-01542830 , version 1 (20-06-2017)

Identifiants

Citer

Tanja Scheikl, Beatrice Pignolet, Cecile Dalard, Sabine Desbois, Daniele Raison, et al.. Cutting Edge: Neuronal Recognition by CD8 T Cells Elicits Central Diabetes Insipidus. Journal of Immunology, 2012, 188 (10), pp.4731-4735. ⟨10.4049/jimmunol.1102998⟩. ⟨hal-01542830⟩
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