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Article Dans Une Revue Journal of Immunology Année : 2012

Cutting Edge: Neuronal Recognition by CD8 T Cells Elicits Central Diabetes Insipidus

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Abstract An increasing number of neurologic diseases is associated with autoimmunity. The immune effectors contributing to the pathogenesis of such diseases are often unclear. To explore whether self-reactive CD8 T cells could attack CNS neurons in vivo, we generated a mouse model in which the influenza virus hemagglutinin (HA) is expressed specifically in CNS neurons. Transfer of cytotoxic anti-HA CD8 T cells induced an acute but reversible encephalomyelitis in HA-expressing recipient mice. Unexpectedly, diabetes insipidus developed in surviving animals. This robust phenotype was associated with preferential accumulation of cytotoxic CD8 T cells in the hypothalamus, upregulation of MHC class I molecules, and destruction of vasopressin-expressing neurons. IFN-γ production by the pathogenic CD8 T cells was necessary for MHC class I upregulation by hypothalamic neurons and their destruction. This novel mouse model, in combination with related human data, supports the concept that autoreactive CD8 T cells can trigger central diabetes insipidus.
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inserm-04284304 , version 1 (14-11-2023)

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Tanja Scheikl, Béatrice Pignolet, Cécile Dalard, Sabine Desbois, Danièle Raison, et al.. Cutting Edge: Neuronal Recognition by CD8 T Cells Elicits Central Diabetes Insipidus. Journal of Immunology, 2012, 188 (10), pp.4731-4735. ⟨10.4049/jimmunol.1102998⟩. ⟨inserm-04284304⟩
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