To remain competitive in currently unpredictable markets, the enterprises must adapt their manufacturing systems to frequent market changes and high product variety. Reconfigurable manufacturing systems (RMSs) promise to offer a rapid and cost-effective response to production fluctuations under the condition that their configuration is attentively studied and optimised. This paper presents a decision support tool for designing reconfigurable machining systems to be used for family part production. The objective is to elaborate a cost-effective solution for production of several part families. This design issue is modelled as a combinatorial optimization problem. An illustrative example and computational experiments are discussed to reveal the application of the proposed methodology. Insight gained would be useful to the decision makers managing the configuration of manufacturing systems for diversified products.