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Article Dans Une Revue Immunologic Research Année : 2016

Diagnostic performance of a new vimentin-derived ACPA (CCP high ă sensitive) in patients with rheumatoid arthritis

Résumé

Autoantibodies are a common feature of rheumatoid arthritis (RA), and ă their detection is used as a diagnostic tool in medical practice. ă Rheumatoid factor (RF) and/or anti-citrullinated protein antibodies ă (ACPA) detection in patients' sera are now included in 2010 ACR/EULAR ă criteria for RA diagnosis. In this study, we evaluated a new ă vimentin-derived ACPA ELISA, the anti-cyclic citrullinated peptide high ă sensitive (CCP hs) test, and we compared its performance with the RF IgM ă and anti-CCP3 tests on a French multicenter cohort of 84 RA patients, ă 107 non-RA patients and 100 healthy controls. Sensitivities for RA ă diagnosis were 71.4, 84.5 and 64.3 % and specificities were 88.4, 86.9 ă and 87.3 % for CCP hs, CCP3 and RF IgM, respectively. There was a ă moderate correlation between CCP hs and CCP3 titers (Pearson's r = 0.43; ă p < 0.0001). These results support the contention that anti-CCP hs ă antibodies are new reliable ACPA with high specificity for RA.
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Dates et versions

hal-01477818 , version 1 (27-02-2017)

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Citer

Daniel Bertin, Sylvain Dubucquoi, Daniela Lakomy, Anne-Sophie Ă Deleplancque, Sophie Desplat-Jégo. Diagnostic performance of a new vimentin-derived ACPA (CCP high ă sensitive) in patients with rheumatoid arthritis. Immunologic Research, 2016, 64 (2), pp.455-460. ⟨10.1007/s12026-015-8690-9⟩. ⟨hal-01477818⟩
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