In the frame of the SAMCO project designed for mountain risk assessment in a context of global change, we developed a systemic approach to assess three specific components of vulnerability – physical, social and institu- tional – for the six municipalities of the Upper Guil catchment (Ristolas, Abriès, Aiguilles, Château-Ville-Vieille, Molines-en-Queyras and St-Véran). Physical vulnerability, which represents total potential consequences of hazards on stakes, was estimated and mapped using a GIS model based on an empirical semi-quantitative indicator, the Potential Damage Index (PDI). This index allowed us to quantify and describe both direct (physical injury, structural and functional damage on buildings, network and land cover) and indirect consequences (socio-economic impacts) induced by hazards, by combining weighted parameters (age, state, material, function, etc.) reflecting the exposure of elements at risk. At least 1890 buildings, 367 km2 of land cover and 902 km of linear infrastructure were considered. To assess social and institutional vulnerability our approach was based on questionnaires (5% of the total population investigated), interviews and mental maps (80 collected) dealing with risk perception, risk memory, mitigation measures and degree of confidence in the actors of risk management. he most endangered areas are both located on alluvial fan and flood plain or in new housing estate (Garcine, Château Renard). These results contribute to a better assessment of the global vulnerability of the the upper Queyras Region to hydrogeomorphic hazards. They could be used to help local authorities to improve and update their Emergency Action plan or their prevention plan.