Purification of organic acids by chromatography with strong anionic resins: Investigation of uptake mechanisms - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Chromatography A Année : 2016

Purification of organic acids by chromatography with strong anionic resins: Investigation of uptake mechanisms

Résumé

Bio-based organic acids are promising renewable carbon sources for the chemical industry. However energy-consuming purification processes are used, like distillation or crystallization, to reach high purities required in some applications. That is why preparative chromatography was studied as an alternative separation technique. In a previous work dealing with the purification of lactic, succinic and citric acids, the Langmuir model was insufficient to explain the elution profiles obtained with a strong anionic resin. Consequently the Langmuir model was coupled with a usual ion-exchange model to take into account the retention of their conjugate bases (<2%), which are commonly neglected at low pH (<1.5). Elution simulations with both uptake mechanisms fitted very well with experimental pulse tests. Only two parameters were optimized (equilibrium constant of acid uptake and ion-exchange selectivity coefficient of conjugate base) and their value were coherent with experimental and resin suppliers’ data. These results confirmed that the singular tailing and apparent delay observed with succinic and citric acids can be explained by the high affinity of succinate and citrate for resin cationic sites. The model was implemented in a preparative chromatography simulation program in order to optimize operating parameters of our pilot-scale ISMB unit (Improved Simulated Moving Bed). The comparison with experimental ISMB profiles was conclusive.
Fichier principal
Vignette du fichier
Manuscript - Lemaire 2016 - JCA - version finale.pdf (876.6 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-01363370 , version 1 (09-11-2016)

Identifiants

Citer

Julien Lemaire, Claire-Line Blanc, Florence Lutin, Marc-André Theoleyre, Moncef Stambouli, et al.. Purification of organic acids by chromatography with strong anionic resins: Investigation of uptake mechanisms. Journal of Chromatography A, 2016, 1458, pp.63-69. ⟨10.1016/j.chroma.2016.06.057⟩. ⟨hal-01363370⟩
123 Consultations
1074 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More