The automated man-made object detection and building extraction from single satellite images is, still, one of the most challenging tasks for various urban planning and monitoring engineering applications. To this end, in this paper we propose an automated building detection framework from very high resolution remote sensing data based on deep convolu-tional neural networks. The core of the developed method is based on a supervised classification procedure employing a very large training dataset. An MRF model is then responsible for obtaining the optimal labels regarding the detection of scene buildings. The experimental results and the performed quantitative validation indicate the quite promising potentials of the developed approach.