Efficacy of tocilizumab in two patients with anti-TNF-alpha refractory uveitis - Archive ouverte HAL Access content directly
Journal Articles Ocular Immunology and Inflammation Year : 2011

Efficacy of tocilizumab in two patients with anti-TNF-alpha refractory uveitis

Abstract

PURPOSE: To report on two patients with refractory uveitis treated with tocilizumab; a new humanized monoclonal antibody against the interleukin-6 receptor (IL-6R). DESIGN: Retrospective interventional case series. METHODS: Both patients received a monthly infusion of tocilizumab 8 mg/kg; associated with corticosteroids. Outcome measures were visual acuity and central retinal thickness evaluated with optical coherence tomography. RESULTS: An improvement in visual acuity and a decrease in macular edema were observed in these two patients. CONCLUSIONS: Tocilizumab seems to be a promising treatment in refractory uveitis. A prospective study is needed to evaluate the role of this new agent in the management of refractory uveitis.
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hal-01183023 , version 1 (05-08-2015)

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Aurore Muselier, Philip Bielefeld, Samuel Bidot, Julien Vinit, Jean-François Besancenot, et al.. Efficacy of tocilizumab in two patients with anti-TNF-alpha refractory uveitis. Ocular Immunology and Inflammation, 2011, 19 (5), pp.382-383. ⟨10.3109/09273948.2011.606593⟩. ⟨hal-01183023⟩
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