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Article Dans Une Revue Aging and disease Année : 2014

Regulation and Role of TGFβ Signaling Pathway in Aging and Osteoarthritis Joints

Résumé

Transforming growth factor beta (TGFβ) is a major signalling pathway in joints. This superfamilly is involved in numerous cellular processes in cartilage. Usually, they are considered to favor chondrocyte differentiation and cartilage repair. However, other studies show also deleterious effects of TGFβ which may induce hypertrophy. This may be explained at least in part by alteration of TGFβ signaling pathways in aging chondrocytes. This review focuses on the functions of TGFβ in joints and the regulation of its signaling mediators (receptors, Smads) during aging and osteoarthritis.
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hal-01147762 , version 1 (01-05-2015)

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Catherine Baugé, Nicolas Girard, Eva Lhuissier, Celine Bazille, Karim Boumediene. Regulation and Role of TGFβ Signaling Pathway in Aging and Osteoarthritis Joints. Aging and disease, 2014, 5 (6), pp.394-405. ⟨10.14336/AD.2014.0500394⟩. ⟨hal-01147762⟩
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