We prove the null controllability, in arbitrary positive time, of the Kolmogorov equation ∂t + v · ∇x − ∆v with (x, v) ∈ R d × R d , with a control region of the form ω = ωx × ωv, where both ωx and ωv are open subsets of R d that are sufficiently spread out throughout the whole space R d. The proof is based on, on the one hand, a spectral inequality in R d with an observation on ωx, and, on the other hand, a Carleman-based observability inequality for a family of parabolic operators, ∂t − iv · ξ − ∆v, coupled with a knowledge of the decay rate of the free solutions of the Kolmogorov equation.