Electrical source imaging in cortical malformation-related epilepsy: a prospective EEG-SEEG concordance study
Estelle Rikir
(1)
,
Laurent Koessler
(2)
,
Martine Gavaret
(3)
,
Fabrice Bartolomei
(4)
,
Sophie Colnat-Coulbois
(5, 6)
,
Jean-Pierre Vignal
(2, 7)
,
Hervé Vespignani
(2)
,
Georgia Ramantani
(8)
,
Louis Maillard
(2, 9)
1
INGI -
Département d'Ingénierie Informatique - UCL
2 CRAN - Centre de Recherche en Automatique de Nancy
3 INS - Institut de Neurosciences des Systèmes
4 Service de Neurophysiologie Clinique
5 Service de Neurochirurgie [CHRU Nancy]
6 DevAH - Développement, Adaptation et Handicap
7 Service de neurologie [CHRU Nancy]
8 Epilepsy Centre
9 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
2 CRAN - Centre de Recherche en Automatique de Nancy
3 INS - Institut de Neurosciences des Systèmes
4 Service de Neurophysiologie Clinique
5 Service de Neurochirurgie [CHRU Nancy]
6 DevAH - Développement, Adaptation et Handicap
7 Service de neurologie [CHRU Nancy]
8 Epilepsy Centre
9 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
Laurent Koessler
- Fonction : Auteur
- PersonId : 179645
- IdHAL : laurent-koessler
- ORCID : 0000-0001-9009-444X
- IdRef : 133412210
Martine Gavaret
- Fonction : Auteur
- PersonId : 762056
- ORCID : 0000-0002-5790-2254
- IdRef : 111048060
Fabrice Bartolomei
- Fonction : Auteur
- PersonId : 178940
- IdHAL : fabrice-bartolomei
- ORCID : 0000-0002-1678-0297
- IdRef : 144324431
Sophie Colnat-Coulbois
- Fonction : Auteur
- PersonId : 786933
- ORCID : 0000-0003-1987-857X
- IdRef : 096245859
Résumé
Objective : Delineation of the epileptogenic zone (EZ) in refractory epilepsy related to malformations of cortical development (MCDs) often requires intracranial electroencephalography (EEG) recordings, especially in cases of negative magnetic resonance imaging (MRI) or discordant MRI and video-EEG findings. It is therefore crucial to promote the development of noninvasive methods such as electrical source imaging (ESI). We aimed to (1) analyze the localization concordance of ESI derived from interictal discharges and EZ estimated by stereo-EEG (SEEG); (2) compare the concordance of ESI, MRI, and electroclinical correlations (ECCs) with SEEG-EZ; and (3) assess ESI added value in the EZ localization.
Methods : We prospectively analyzed 28 consecutive patients undergoing presurgical investigation for MCD-related refractory epilepsy in 2009–2012. ESI derived from 64-channel scalp EEG was interpreted with blinding to, and subsequently compared with, SEEG-estimated EZ. Anatomic concordance of ESI with SEEG-EZ was compared with that of video-EEG and MRI. We further assessed ESI added value to ECC and MRI.
Results : Twelve patients (43%) had temporal and 16 (57%) had extratemporal epilepsy. MRI was negative in 11 (39%) and revealed a cortical malformation in 17 (61%). ESI was fully concordant with the EZ in 10 (36%) and partly concordant in 15 (53%). ECC presented a full and partial concordance with EZ in 11% and 82% of cases, respectively, and MRI in 11% and 46%, respectively. Of 11 patients with negative MRI, ESI was fully concordant with the EZ in 7 (64%) and partly concordant in 4 (36%). ESI correctly confirmed restricted or added localizations to ECC and MRI in 12 (43%) of 28 patients and in 8 (73%) of 11 patients with negative MRI.
Significance : ESI contributes to estimating the EZ in MCD-related epilepsy. The added value of ESI to ECC is particularly high in patients with MCD and negative MRI, who represent the most challenging cases for epilepsy surgery.
Domaines
Automatique / RobotiqueFormat du dépôt | Notice |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
Electrical source imaging in cortical malformation-related epilepsy: a prospective EEG-SEEG concordance study
|
Résumé |
en
Objective : Delineation of the epileptogenic zone (EZ) in refractory epilepsy related to malformations of cortical development (MCDs) often requires intracranial electroencephalography (EEG) recordings, especially in cases of negative magnetic resonance imaging (MRI) or discordant MRI and video-EEG findings. It is therefore crucial to promote the development of noninvasive methods such as electrical source imaging (ESI). We aimed to (1) analyze the localization concordance of ESI derived from interictal discharges and EZ estimated by stereo-EEG (SEEG); (2) compare the concordance of ESI, MRI, and electroclinical correlations (ECCs) with SEEG-EZ; and (3) assess ESI added value in the EZ localization.
Methods : We prospectively analyzed 28 consecutive patients undergoing presurgical investigation for MCD-related refractory epilepsy in 2009–2012. ESI derived from 64-channel scalp EEG was interpreted with blinding to, and subsequently compared with, SEEG-estimated EZ. Anatomic concordance of ESI with SEEG-EZ was compared with that of video-EEG and MRI. We further assessed ESI added value to ECC and MRI.
Results : Twelve patients (43%) had temporal and 16 (57%) had extratemporal epilepsy. MRI was negative in 11 (39%) and revealed a cortical malformation in 17 (61%). ESI was fully concordant with the EZ in 10 (36%) and partly concordant in 15 (53%). ECC presented a full and partial concordance with EZ in 11% and 82% of cases, respectively, and MRI in 11% and 46%, respectively. Of 11 patients with negative MRI, ESI was fully concordant with the EZ in 7 (64%) and partly concordant in 4 (36%). ESI correctly confirmed restricted or added localizations to ECC and MRI in 12 (43%) of 28 patients and in 8 (73%) of 11 patients with negative MRI.
Significance : ESI contributes to estimating the EZ in MCD-related epilepsy. The added value of ESI to ECC is particularly high in patients with MCD and negative MRI, who represent the most challenging cases for epilepsy surgery.
|
Auteur(s) |
Estelle Rikir
1
, Laurent Koessler
2
, Martine Gavaret
3
, Fabrice Bartolomei
4
, Sophie Colnat-Coulbois
5, 6
, Jean-Pierre Vignal
2, 7
, Hervé Vespignani
2
, Georgia Ramantani
8
, Louis Maillard
2, 9
1
INGI -
Département d'Ingénierie Informatique - UCL
( 17018 )
- Université catholique de Louvain Département d'ingénierie Informatique Department of Computing Science and Engineering 2, Place Sainte-Barbe B-1348 Louvain-la-Neuve
- Belgique
2
CRAN -
Centre de Recherche en Automatique de Nancy
( 185180 )
- Université de Lorraine, Campus Sciences, BP 70239, 54506 Vandoeuvre-les-Nancy Cedex
- France
3
INS -
Institut de Neurosciences des Systèmes
( 220661 )
- Faculté de Médecine - Secteur Timone - 27 boulevard Jean Moulin 13385 Marseille Cedex 05
- France
4
Service de Neurophysiologie Clinique
( 55128 )
- 264, rue Saint Pierre 13385 Marseille Cedex 5
- France
5
Service de Neurochirurgie [CHRU Nancy]
( 526012 )
- France
6
DevAH -
Développement, Adaptation et Handicap
( 444382 )
- Université de Lorraine, Faculté de Médecine, 9 avenue de la Forêt de Haye, 54500 Vandoeuvre-les-Nancy
- France
7
Service de neurologie [CHRU Nancy]
( 201712 )
- 29, avenue du Maréchal de Lattre de Tassigny CO 60034 - 54035 NANCY CEDEX
- France
8
Epilepsy Centre
( 155198 )
- Freiburg
- Allemagne
9
CHRU Nancy -
Centre Hospitalier Régional Universitaire de Nancy
( 300157 )
- Siège social : 29 avenue du Maréchal de Lattre de Tassigny, CO 60034, 54035 NANCY CEDEX
Hôpital Central : 29 Avenue du Maréchal de Lattre de Tassigny, 54035 Nancy
Hôpitaux de Brabois / Enfants : Rue du Morvan, 54500 Vandœuvre-lès-Nancy
Maternité régionale :10 Avenue Dr Heydenreich, 54000 Nancy
- France
|
Comité de lecture |
Oui
|
Vulgarisation |
Non
|
Nom de la revue |
|
Langue du document |
Anglais
|
Audience |
Internationale
|
Date de publication |
2014-06
|
Volume |
55
|
Numéro |
6
|
Page/Identifiant |
918-932
|
Référence interne |
|
Domaine(s) |
|
Mots-clés |
en
Stereo-EEG, Malformations of cortical development, Electrical source imaging
|
DOI | 10.1111/epi.12591 |
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