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Communication Dans Un Congrès Année : 2012

Early nutrition, epigenetics and sexual dimorphism: divergent developmental programming trajectories may provide sex-specific cues for dietary alleviation

Résumé

Maternal weight dynamics before conception plays a role in the process of early-life programming but there is an almost complete lack of evaluation of the effects of dietary strategies before or during in pregnancy on the long term effects for offspring. Moreover defining the impact of paternal nutrition on health of offspring will provide the basis for novel approaches to its optimization. Biomarkers of susceptibility to subsequent chronic disease would have enormous implications for the management of major public health issues. Epigenetic modifications fix the effects of early environmental events, ensuring sustained responses to Stage-sex- and cell-specific epigenetic landscapes, crosstalk between the different epigenetic marks, in an on-going elf-propagating epigenetic cycle with stable metabolic memories and ageing processes are emerging. Unravelling epigenetic mechanisms and marks during key developmental periods and their evolution with diet, lifestyle and time, will provide science-based markers and targets for intervention and recommendations before pregnancy in both parents and during critical developmental periods. Since there is mounting evidence that placenta can be considered as a programming agent, adaptations in placental phenotype may, therefore, be an important epigenetic mechanism by which maternal diet alters fetal nutrient provision independently of the dietary induced changes in maternal nutrient availability. Sexually dimorphic modules of networks corresponding to highly correlated gene expression related to genetic and modules of networks corresponding to highly correlated gene expression related to genetic and metabolic traits, and for genes affected by gonadal hormones ave been identified in adipose, brain, liver, and muscle, and in placenta. Understanding these factors and the sex-specific genetic and epigenetic architecture of human disease could uncover sex-specific protective forces that are attractive targets for novel therapies. Our research strategy is to transfer the knowledge acquired in appropriate animal models using a comprehensive approach, back to a collection of human placenta (ProgEpiPlac coord. C. Junien) and tissues from bariatric surgery patients (ABOS Collection, F Pattou, Lille), and thus to the clinical and public health context from which the questions arose. Our goal is to propose and initiate further testing of relevant evidence-based dietary/lifestyle recommendations, to reverse or cope with adverse dietary programming, by unlocking specific epigenetic conditions or reinstating plasticity. Improving the nutritional environment to which an individual is exposed during early development may prevent the viciois cycle of intergenerational epidemics of obesity.
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Dates et versions

hal-01019200 , version 1 (07-07-2014)

Identifiants

  • HAL Id : hal-01019200 , version 1
  • PRODINRA : 253482

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Claudine Junien, Linda Attig, Anne Gabory. Early nutrition, epigenetics and sexual dimorphism: divergent developmental programming trajectories may provide sex-specific cues for dietary alleviation. Symposium on the Functional Genomics of Early Development in Livestock, University of Alberta. Alberta, CAN., Jul 2012, Alberta, Canada. pp.18. ⟨hal-01019200⟩
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