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Welcome to the BREED publications collection
The Biology of Reproduction, Environment, Epigenetics and Development (BREED) joint research unit studies the effects of environment, in the broadest sense, on reproduction, development during embryonic and foetal life and the health of offspring. It gathers researchers, hospital clinicians and veterinarians for both agronomic and biomedical research.
The scientific context is based on the need to understand and control the mechanisms of epigenetic programming during prenatal life leading to the birth of a healthy, fertile and robust individual, capable of adapting to changes in its environment.
The aims of our research are to improve fertility and the efficiency of reproductive biotechnologies in humans and animals, to study the physiological and molecular mechanisms that determine the phenotypes of the offspring (health, growth, fertility, etc.) and to identify predictive and non-invasive biomarkers for these phenotypes, some of which could complement genetic selection strategies in animals. The unit relies on research involving several animal models (rabbits, ruminants, rodents, horses) and multiple and complementary imaging approaches, from the microscopic scale to the whole live animal. In vitro models are also developed as alternatives to animal experimentation (primary cell cultures, organoids, embryoids). This expertise and tools are complemented by clinical studies conducted by hospital and veterinary practitioners.
Last additions
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Dorothee Ledoux, Isabelle Veissier, Bruno Meunier, Valerie Gelin, Christophe Richard, et al.. Combining accelerometers and direct visual observations to detect sickness and pain in cows of different ages submitted to systemic inflammation. Scientific Reports, 2023, 13 (1), pp.1977. ⟨10.1038/s41598-023-27884-x⟩. ⟨hal-03975769⟩
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Ophélie Téteau, Anaïs Vitorino Carvalho, Pascal Papillier, Béatrice Mandon-Pepin, Luc Jouneau, et al.. Bisphenol A and bisphenol S both disrupt ovine granulosa cell steroidogenesis but through different molecular pathways. Journal of Ovarian Research, 2023, 16 (1), pp.30. ⟨10.1186/s13048-023-01114-4⟩. ⟨hal-03972669⟩
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Mariana Mescouto Lopes, Caroline Clouard, Jennifer Chambeaud, Manon Brien, Nicolas Villain, et al.. Impact of environmental enrichment on the behaviour and immune cell transcriptome of pregnant sows. 74. Annual meeting of the european federation of animal science (EAAP), INRAE; EAAP, Aug 2023, Lyon, France. pp.887. ⟨hal-04207105⟩
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Laurent Galio, Laetitia Bernet, Yoann Rodriguez, Camille Fourcault, Marie‐noëlle Dieudonné, et al.. The effect of obesity on uterine receptivity is mediated by endometrial extracellular vesicles that control human endometrial stromal cell decidualization and trophoblast invasion. Journal of Extracellular Biology, 2023, 2 (7), ⟨10.1002/jex2.103⟩. ⟨hal-04165774⟩
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Rossella Cannarella, Rupin Shah, Taha Abo-Almagd Abdel-Meguid Hamoda, Florence Boitrelle, Ramadan Saleh, et al.. Does Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study of Before-After Data. The World Journal of Men's Health, 2023, 41, ⟨10.5534/wjmh.230034⟩. ⟨hal-04149299⟩
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Mahendra Mariadassou, Laurent-Xavier Nouvel, Fabienne Constant, Diego P. Morgavi, Lucie Rault, et al.. Microbiota members from body sites of dairy cows are largely shared within individual hosts throughout lactation but sharing is limited in the herd. Animal Microbiome, 2023, 5 (1), pp.32. ⟨10.1186/s42523-023-00252-w⟩. ⟨hal-04126196⟩
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Mahendra Mariadassou, Laurent X Nouvel, Fabienne Constant, Diego P Morgavi, Lucie Rault, et al.. Microbiota members from body sites of dairy cows are largely shared within individual hosts throughout lactation but sharing is limited in the herd. Animal Microbiome, 2023, 5 (32), pp.1-17. ⟨10.1186/s42523-023-00252-w⟩. ⟨hal-04204329⟩
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E. Ivanova, Catherine Hue-Beauvais, Aurélie Chaulot-Talmon, J. Castille, J Laubier, et al.. DNA methylation and gene expression changes in mouse mammary tissue during successive lactations: part I – the impact of inflammation. Epigenetics, 2023, 18 (1), ⟨10.1080/15592294.2023.2215633⟩. ⟨hal-04127637⟩
References
2 151
Open Access
32 %
Keywords
Mice
Foetus
Dna methylation
Uterus
Dohad
GENETIQUE
Blastocyst
NUCLEAR TRANSFER
BIOLOGIE DU DEVELOPPEMENT
Growth
Ovary
Nutrition
PLACENTA
Epigenetics
Ruminant
Endomètre
RAT
Conceptus
Diesel
BIOTECHNOLOGIE
Fetal programming
Infertility
Horse
Progesterone
Equine
Programming
Spermatogenesis
IMMUNOLOGIE
Méthylation
Souris
Gestation
Mammary gland
Embryo development
Développement
Male
Oxidative stress
Development
Sheep
DNA methylation
Sex determination
Transcriptome
Somatic cell nuclear transfer
Rabbit
GENOMIQUE
Pluripotency
Meiosis
Gene expression
Animal model
Sexual dimorphism
Oocyte
DOHaD
Cheval
Sperm
Adult
Placenta
Phénotype
Mouse
IMAGE
Programmation foetale
Methylation
Bovin
Implantation
Reproduction
Trophoblast
Animal modèle
Épigénétique
Male infertility
Pregnancy
Nuclear transfer
Epigenetic
Embryon
Jument
Environment
Female
Obésité
Goat
Foxl2
Fertility
Bovine
These
Embryo transfer
Alimentation
Fertilité
Dairy cow
Humans
Lapin
EMBRYO
Développement embryonnaire
IMAGERIE
Ovaire
Mare
Animal models
Cattle
Poulain
Embryo
Epigénétique
Obesity
Endometrium
Chorion
Métabolisme