Welcome to the BREED publications collection
The Biology of Reproduction, Environment, Epigenetics and Development (BREED) joint research unit studies the effects of environment, in the broadest sense, on reproduction, development during embryonic and foetal life and the health of offspring. It gathers researchers, hospital clinicians and veterinarians for both agronomic and biomedical research.
The scientific context is based on the need to understand and control the mechanisms of epigenetic programming during prenatal life leading to the birth of a healthy, fertile and robust individual, capable of adapting to changes in its environment.
The aims of our research are to improve fertility and the efficiency of reproductive biotechnologies in humans and animals, to study the physiological and molecular mechanisms that determine the phenotypes of the offspring (health, growth, fertility, etc.) and to identify predictive and non-invasive biomarkers for these phenotypes, some of which could complement genetic selection strategies in animals. The unit relies on research involving several animal models (rabbits, ruminants, rodents, horses) and multiple and complementary imaging approaches, from the microscopic scale to the whole live animal. In vitro models are also developed as alternatives to animal experimentation (primary cell cultures, organoids, embryoids). This expertise and tools are complemented by clinical studies conducted by hospital and veterinary practitioners.
Last additions
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Jeanne Bozec, Delphine Rousseau-Ralliard, Luc Jouneau, Audrey Prézelin, Michèle Dahirel, et al.. Preconception and/or preimplantation exposure to a mixture of environmental contaminants altered fetoplacental development and placental function in a rabbit model. Environmental Research, 2024, 262, pp.119829. ⟨10.1016/j.envres.2024.119829⟩. ⟨hal-04683426⟩
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Leticia Casarotto Trevisan, Pascale Chavatte-Palmer, Geoffrey Dahl. P2.18- Late gestation heat stress impact on placental morphology and fetal development in ewes.. International Federation of Placenta Associations, International Federation of Placenta Associations, Sep 2024, Montreal, Canada. pp.e52. ⟨hal-04703913⟩
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Suelen Fernandes Padilha, Adriana Mércia Guaratini Ibelli, Jane Oliveira Peixoto, Maurício Egídio Cantão, Gabriel Costa Monteiro Moreira, et al.. Novel Candidate Genes Involved in an Initial Stage of White Striping Development in Broiler Chickens. Animals, 2024, 14, ⟨10.3390/ani14162379⟩. ⟨hal-04683411⟩
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Sara El Fouikar, Nathalie van Acker, Virginie Héliès, François-Xavier Frenois, Frank Giton, et al.. Folliculogenesis and steroidogenesis alterations after chronic exposure to a human-relevant mixture of environmental toxicants spare the ovarian reserve in the rabbit model. Journal of Ovarian Research, 2024, 17, ⟨10.1186/s13048-024-01457-6⟩. ⟨hal-04638003⟩
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