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Welcome to the BREED publications collection
The Biology of Reproduction, Environment, Epigenetics and Development (BREED) joint research unit studies the effects of environment, in the broadest sense, on reproduction, development during embryonic and foetal life and the health of offspring. It gathers researchers, hospital clinicians and veterinarians for both agronomic and biomedical research.
The scientific context is based on the need to understand and control the mechanisms of epigenetic programming during prenatal life leading to the birth of a healthy, fertile and robust individual, capable of adapting to changes in its environment.
The aims of our research are to improve fertility and the efficiency of reproductive biotechnologies in humans and animals, to study the physiological and molecular mechanisms that determine the phenotypes of the offspring (health, growth, fertility, etc.) and to identify predictive and non-invasive biomarkers for these phenotypes, some of which could complement genetic selection strategies in animals. The unit relies on research involving several animal models (rabbits, ruminants, rodents, horses) and multiple and complementary imaging approaches, from the microscopic scale to the whole live animal. In vitro models are also developed as alternatives to animal experimentation (primary cell cultures, organoids, embryoids). This expertise and tools are complemented by clinical studies conducted by hospital and veterinary practitioners.
Last additions
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Dorothee Ledoux, Isabelle Veissier, Bruno Meunier, Valerie Gelin, Christophe Richard, et al.. Combining accelerometers and direct visual observations to detect sickness and pain in cows of different ages submitted to systemic inflammation. Scientific Reports, 2023, 13 (1), pp.1977. ⟨10.1038/s41598-023-27884-x⟩. ⟨hal-03975769⟩
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Ophélie Téteau, Anaïs Vitorino Carvalho, Pascal Papillier, Béatrice Mandon-Pepin, Luc Jouneau, et al.. Bisphenol A and bisphenol S both disrupt ovine granulosa cell steroidogenesis but through different molecular pathways. Journal of Ovarian Research, 2023, 16 (1), pp.30. ⟨10.1186/s13048-023-01114-4⟩. ⟨hal-03972669⟩
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Mariana Mescouto Lopes, Caroline Clouard, Jennifer Chambeaud, Manon Brien, Nicolas Villain, et al.. Impact of environmental enrichment on the behaviour and immune cell transcriptome of pregnant sows. 74. Annual meeting of the european federation of animal science (EAAP), INRAE; EAAP, Aug 2023, Lyon, France. pp.887. ⟨hal-04207105⟩
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Laurent Galio, Laetitia Bernet, Yoann Rodriguez, Camille Fourcault, Marie‐noëlle Dieudonné, et al.. The effect of obesity on uterine receptivity is mediated by endometrial extracellular vesicles that control human endometrial stromal cell decidualization and trophoblast invasion. Journal of Extracellular Biology, 2023, 2 (7), ⟨10.1002/jex2.103⟩. ⟨hal-04165774⟩
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Rossella Cannarella, Rupin Shah, Taha Abo-Almagd Abdel-Meguid Hamoda, Florence Boitrelle, Ramadan Saleh, et al.. Does Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study of Before-After Data. The World Journal of Men's Health, 2023, 41, ⟨10.5534/wjmh.230034⟩. ⟨hal-04149299⟩
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Mahendra Mariadassou, Laurent-Xavier Nouvel, Fabienne Constant, Diego P. Morgavi, Lucie Rault, et al.. Microbiota members from body sites of dairy cows are largely shared within individual hosts throughout lactation but sharing is limited in the herd. Animal Microbiome, 2023, 5 (1), pp.32. ⟨10.1186/s42523-023-00252-w⟩. ⟨hal-04126196⟩
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E. Ivanova, Catherine Hue-Beauvais, Aurélie Chaulot-Talmon, J. Castille, J Laubier, et al.. DNA methylation and gene expression changes in mouse mammary tissue during successive lactations: part I – the impact of inflammation. Epigenetics, 2023, 18 (1), ⟨10.1080/15592294.2023.2215633⟩. ⟨hal-04127637⟩
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References
2 156
Open Access
32 %
Keywords
Implantation
Fertilité
Methylation
DOHaD
Horse
Infertility
Ruminant
Sex determination
Ovary
Mare
Sperm
Sheep
Female
Adult
Somatic cell nuclear transfer
Animal models
Environment
Lapin
Nutrition
Pluripotency
EMBRYO
Obésité
Equine
Nuclear transfer
Métabolisme
Development
Animal model
Phénotype
Cattle
DNA methylation
Foxl2
Obesity
Développement embryonnaire
IMAGE
Gestation
IMAGERIE
Rabbit
Bovin
Epigenetic
Développement
Souris
Épigénétique
Poulain
Foetus
Reproduction
Animal modèle
Oxidative stress
BIOTECHNOLOGIE
Meiosis
PLACENTA
Fertility
Spermatogenesis
Embryo development
Progesterone
Growth
These
Placenta
Mice
NUCLEAR TRANSFER
Embryo
Blastocyst
Gene expression
IMMUNOLOGIE
GENETIQUE
Conceptus
Endomètre
BIOLOGIE DU DEVELOPPEMENT
Dna methylation
Bovine
Transcriptome
Goat
Fetal programming
Chorion
Alimentation
GENOMIQUE
Humans
Male infertility
Méthylation
Oocyte
Jument
Programmation foetale
Dohad
Trophoblast
Mammary gland
Uterus
Programming
Male
Sexual dimorphism
Ovaire
Cheval
Dairy cow
Epigenetics
RAT
Mouse
Embryo transfer
Pregnancy
Endometrium
Embryon
Epigénétique
Diesel