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Welcome to the BREED publications collection
The Biology of Reproduction, Environment, Epigenetics and Development (BREED) joint research unit studies the effects of environment, in the broadest sense, on reproduction, development during embryonic and foetal life and the health of offspring. It gathers researchers, hospital clinicians and veterinarians for both agronomic and biomedical research.
The scientific context is based on the need to understand and control the mechanisms of epigenetic programming during prenatal life leading to the birth of a healthy, fertile and robust individual, capable of adapting to changes in its environment.
The aims of our research are to improve fertility and the efficiency of reproductive biotechnologies in humans and animals, to study the physiological and molecular mechanisms that determine the phenotypes of the offspring (health, growth, fertility, etc.) and to identify predictive and non-invasive biomarkers for these phenotypes, some of which could complement genetic selection strategies in animals. The unit relies on research involving several animal models (rabbits, ruminants, rodents, horses) and multiple and complementary imaging approaches, from the microscopic scale to the whole live animal. In vitro models are also developed as alternatives to animal experimentation (primary cell cultures, organoids, embryoids). This expertise and tools are complemented by clinical studies conducted by hospital and veterinary practitioners.
Last additions
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E Ivanova, Catherine Hue-Beauvais, Aurélie Chaulot-Talmon, J Castille, J Laubier, et al.. DNA methylation and gene expression changes in mouse mammary tissue during successive lactations: part II – the impact of lactation rank. Epigenetics, 2023, 18 (1), pp.2215620. ⟨10.1080/15592294.2023.2215620⟩. ⟨hal-04116796⟩
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Ophélie Téteau, Anaïs Vitorino Carvalho, Pascal Papillier, Béatrice Mandon-Pepin, Luc Jouneau, et al.. Bisphenol A and bisphenol S both disrupt ovine granulosa cell steroidogenesis but through different molecular pathways. Journal of Ovarian Research, 2023, 16 (1), pp.30. ⟨10.1186/s13048-023-01114-4⟩. ⟨hal-03972669⟩
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Eva Bongaerts, Tim S Nawrot, Congrong Wang, Marcel Ameloot, Hannelore Bové, et al.. Placental-fetal distribution of carbon particles in a pregnant rabbit model after repeated exposure to diluted diesel engine exhaust. Particle and Fibre Toxicology, 2023, 20, ⟨10.1186/s12989-023-00531-z⟩. ⟨hal-04106052⟩
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Sara El Fouikar, Véronique Duranthon, Virginie Helies, Hélène Jammes, Anne Couturier-Tarrade, et al.. Multigenerational Effects of a Complex Human-Relevant Exposure during Folliculogenesis and Preimplantation Embryo Development: The FEDEXPO Study. Toxics, 2023, 11 (5), pp.425. ⟨10.3390/toxics11050425⟩. ⟨hal-04112370⟩
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Bérangère Coutanceau, Esther dos Santos, Nelly Swierkowski Blanchard, Anne Sanchez Louboutin, Florence Boitrelle, et al.. Should the Treatment of Patients with Repeated Embryo Implantation Failure Be Adapted as a Function of the Endometrial Cytokine Profile? A Single-Center Experience. Biomedicines, 2023, 11 (3), pp.817. ⟨10.3390/biomedicines11030817⟩. ⟨hal-04056031⟩
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References
2 124
Open Access
32 %
Keywords
GENOMIQUE
Sex determination
Foetus
RAT
Cheval
Nutrition
Programming
Bovin
Bovine
Male
BIOLOGIE DU DEVELOPPEMENT
Goat
Diesel
Humans
Meiosis
Lapin
DOHaD
Obésité
Programmation foetale
Fetal programming
Endomètre
Epigenetic
Phénotype
Endometrium
Transcriptome
Progesterone
GENETIQUE
Embryo development
Nuclear transfer
Dna methylation
Cow
Embryo transfer
Trophoblast
Animal modèle
Dohad
Métabolisme
EMBRYO
Fertilité
Conceptus
Epigenetics
Poulain
Cattle
PLACENTA
Blastocyst
Methylation
Growth
Développement embryonnaire
Développement
Uterus
Animal models
NUCLEAR TRANSFER
Spermatogenesis
Mice
Placenta
Gene expression
Implantation
These
Jument
Méthylation
Pregnancy
Épigénétique
Alimentation
Mouse
Oxidative stress
BIOTECHNOLOGIE
Gestation
IMMUNOLOGIE
Rabbit
Adult
Somatic cell nuclear transfer
Fertility
Ovaire
Mammary gland
Sperm
Embryon
Ruminant
IMAGERIE
Development
Chorion
IMAGE
Ovary
Female
Animal model
Pluripotency
Sheep
Foxl2
Dairy cow
Horse
Chromatin
Environment
DNA methylation
Souris
Equine
Reproduction
Embryo
Mare
Oocyte
Epigénétique
Obesity
Sexual dimorphism