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Welcome to the BREED publications collection
The Biology of Reproduction, Environment, Epigenetics and Development (BREED) joint research unit studies the effects of environment, in the broadest sense, on reproduction, development during embryonic and foetal life and the health of offspring. It gathers researchers, hospital clinicians and veterinarians for both agronomic and biomedical research.
The scientific context is based on the need to understand and control the mechanisms of epigenetic programming during prenatal life leading to the birth of a healthy, fertile and robust individual, capable of adapting to changes in its environment.
The aims of our research are to improve fertility and the efficiency of reproductive biotechnologies in humans and animals, to study the physiological and molecular mechanisms that determine the phenotypes of the offspring (health, growth, fertility, etc.) and to identify predictive and non-invasive biomarkers for these phenotypes, some of which could complement genetic selection strategies in animals. The unit relies on research involving several animal models (rabbits, ruminants, rodents, horses) and multiple and complementary imaging approaches, from the microscopic scale to the whole live animal. In vitro models are also developed as alternatives to animal experimentation (primary cell cultures, organoids, embryoids). This expertise and tools are complemented by clinical studies conducted by hospital and veterinary practitioners.
Last additions
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Dorothee Ledoux, Isabelle Veissier, Bruno Meunier, Valerie Gelin, Christophe Richard, et al.. Combining accelerometers and direct visual observations to detect sickness and pain in cows of different ages submitted to systemic inflammation. Scientific Reports, 2023, 13 (1), pp.1977. ⟨10.1038/s41598-023-27884-x⟩. ⟨hal-03975769⟩
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Ophélie Téteau, Anaïs Vitorino Carvalho, Pascal Papillier, Béatrice Mandon-Pepin, Luc Jouneau, et al.. Bisphenol A and bisphenol S both disrupt ovine granulosa cell steroidogenesis but through different molecular pathways. Journal of Ovarian Research, 2023, 16 (1), pp.30. ⟨10.1186/s13048-023-01114-4⟩. ⟨hal-03972669⟩
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Mariana Mescouto Lopes, Caroline Clouard, Jennifer Chambeaud, Manon Brien, Nicolas Villain, et al.. Impact of environmental enrichment on the behaviour and immune cell transcriptome of pregnant sows. 74. Annual meeting of the european federation of animal science (EAAP), INRAE; EAAP, Aug 2023, Lyon, France. pp.887. ⟨hal-04207105⟩
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Laurent Galio, Laetitia Bernet, Yoann Rodriguez, Camille Fourcault, Marie‐noëlle Dieudonné, et al.. The effect of obesity on uterine receptivity is mediated by endometrial extracellular vesicles that control human endometrial stromal cell decidualization and trophoblast invasion. Journal of Extracellular Biology, 2023, 2 (7), ⟨10.1002/jex2.103⟩. ⟨hal-04165774⟩
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Rossella Cannarella, Rupin Shah, Taha Abo-Almagd Abdel-Meguid Hamoda, Florence Boitrelle, Ramadan Saleh, et al.. Does Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study of Before-After Data. The World Journal of Men's Health, 2023, 41, ⟨10.5534/wjmh.230034⟩. ⟨hal-04149299⟩
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Mahendra Mariadassou, Laurent-Xavier Nouvel, Fabienne Constant, Diego P. Morgavi, Lucie Rault, et al.. Microbiota members from body sites of dairy cows are largely shared within individual hosts throughout lactation but sharing is limited in the herd. Animal Microbiome, 2023, 5 (1), pp.32. ⟨10.1186/s42523-023-00252-w⟩. ⟨hal-04126196⟩
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Mahendra Mariadassou, Laurent X Nouvel, Fabienne Constant, Diego P Morgavi, Lucie Rault, et al.. Microbiota members from body sites of dairy cows are largely shared within individual hosts throughout lactation but sharing is limited in the herd. Animal Microbiome, 2023, 5 (32), pp.1-17. ⟨10.1186/s42523-023-00252-w⟩. ⟨hal-04204329⟩
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E. Ivanova, Catherine Hue-Beauvais, Aurélie Chaulot-Talmon, J. Castille, J Laubier, et al.. DNA methylation and gene expression changes in mouse mammary tissue during successive lactations: part I – the impact of inflammation. Epigenetics, 2023, 18 (1), ⟨10.1080/15592294.2023.2215633⟩. ⟨hal-04127637⟩
References
2 151
Open Access
32 %
Keywords
Développement
Trophoblast
Epigenetics
Jument
Métabolisme
Bovine
Development
Nutrition
Bovin
Embryon
Goat
Fetal programming
Endomètre
Progesterone
DNA methylation
Spermatogenesis
Blastocyst
Programmation foetale
Sexual dimorphism
Somatic cell nuclear transfer
Cattle
Conceptus
IMMUNOLOGIE
Mammary gland
Mouse
Sperm
EMBRYO
Obesity
DOHaD
Embryo transfer
Cheval
Pluripotency
Lapin
Animal models
Pregnancy
Endometrium
Reproduction
Male infertility
Implantation
Méthylation
Gene expression
Mice
Embryo development
Nuclear transfer
Female
These
Growth
Dohad
Embryo
Epigénétique
Chorion
Equine
GENOMIQUE
Humans
Développement embryonnaire
IMAGE
Meiosis
Foxl2
Ruminant
Ovaire
Poulain
Methylation
Foetus
BIOTECHNOLOGIE
Male
Mare
Gestation
Oocyte
BIOLOGIE DU DEVELOPPEMENT
Diesel
RAT
Rabbit
Programming
Adult
NUCLEAR TRANSFER
Environment
Alimentation
Fertilité
Sex determination
Épigénétique
GENETIQUE
Dairy cow
Souris
Fertility
Epigenetic
Phénotype
PLACENTA
Ovary
Horse
Sheep
Dna methylation
Transcriptome
Uterus
Animal model
IMAGERIE
Oxidative stress
Placenta
Infertility
Animal modèle
Obésité