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Welcome to the BREED publications collection
The Biology of Reproduction, Environment, Epigenetics and Development (BREED) joint research unit studies the effects of environment, in the broadest sense, on reproduction, development during embryonic and foetal life and the health of offspring. It gathers researchers, hospital clinicians and veterinarians for both agronomic and biomedical research.
The scientific context is based on the need to understand and control the mechanisms of epigenetic programming during prenatal life leading to the birth of a healthy, fertile and robust individual, capable of adapting to changes in its environment.
The aims of our research are to improve fertility and the efficiency of reproductive biotechnologies in humans and animals, to study the physiological and molecular mechanisms that determine the phenotypes of the offspring (health, growth, fertility, etc.) and to identify predictive and non-invasive biomarkers for these phenotypes, some of which could complement genetic selection strategies in animals. The unit relies on research involving several animal models (rabbits, ruminants, rodents, horses) and multiple and complementary imaging approaches, from the microscopic scale to the whole live animal. In vitro models are also developed as alternatives to animal experimentation (primary cell cultures, organoids, embryoids). This expertise and tools are complemented by clinical studies conducted by hospital and veterinary practitioners.
Last additions
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Ophélie Téteau, Anaïs Vitorino Carvalho, Pascal Papillier, Béatrice Mandon-Pepin, Luc Jouneau, et al.. Bisphenol A and bisphenol S both disrupt ovine granulosa cell steroidogenesis but through different molecular pathways. Journal of Ovarian Research, 2023, 16 (1), pp.30. ⟨10.1186/s13048-023-01114-4⟩. ⟨hal-03972669⟩
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Eva Bongaerts, Tim S Nawrot, Congrong Wang, Marcel Ameloot, Hannelore Bové, et al.. Placental-fetal distribution of carbon particles in a pregnant rabbit model after repeated exposure to diluted diesel engine exhaust. Particle and Fibre Toxicology, 2023, 20, ⟨10.1186/s12989-023-00531-z⟩. ⟨hal-04107365⟩
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Eva Bongaerts, Tim S Nawrot, Congrong Wang, Marcel Ameloot, Hannelore Bové, et al.. Placental-fetal distribution of carbon particles in a pregnant rabbit model after repeated exposure to diluted diesel engine exhaust. Particle and Fibre Toxicology, 2023, 20, ⟨10.1186/s12989-023-00531-z⟩. ⟨hal-04106052⟩
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Sara El Fouikar, Véronique Duranthon, Virginie Helies, Hélène Jammes, Anne Couturier-Tarrade, et al.. Multigenerational Effects of a Complex Human-Relevant Exposure during Folliculogenesis and Preimplantation Embryo Development: The FEDEXPO Study. Toxics, 2023, 11 (5), pp.425. ⟨10.3390/toxics11050425⟩. ⟨hal-04112370⟩
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Bérangère Coutanceau, Esther dos Santos, Nelly Swierkowski Blanchard, Anne Sanchez Louboutin, Florence Boitrelle, et al.. Should the Treatment of Patients with Repeated Embryo Implantation Failure Be Adapted as a Function of the Endometrial Cytokine Profile? A Single-Center Experience. Biomedicines, 2023, 11 (3), pp.817. ⟨10.3390/biomedicines11030817⟩. ⟨hal-04056031⟩
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Sylvie Chastant, Gary England, Oliver Forman, Alexander German, Jan Suchodolski, et al.. Environmental risk factors in puppies and kittens for developing chronic disorders in adulthood: A call for research on developmental programming. Frontiers in Veterinary Science, 2022, 9, ⟨10.3389/fvets.2022.944821⟩. ⟨hal-03912284⟩
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N. Gafsi, F. Bidan, Bénédicte Grimard, M. Legris, O. Martin, et al.. Relationships between fertility after artificial insemination, milk production dynamics, body reserves and heat stress in Alpine dairy goats. 26. Rencontres autour des Recherches sur les Ruminants (3R 2022), INRAE; IDELE, Dec 2022, Paris, France. pp.372-376. ⟨hal-04039512⟩
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Romina Via y Rada, Nathalie Daniel, Catherine Archilla, Anne Frambourg, Luc Jouneau, et al.. Identification of the Inner Cell Mass and the Trophectoderm Responses after an In Vitro Exposure to Glucose and Insulin during the Preimplantation Period in the Rabbit Embryo. Cells, 2022, 11 (23), pp. 3766. ⟨10.3390/cells11233766⟩. ⟨hal-03871680⟩
References

Open Access

Keywords
DOHaD
Dna methylation
Trophoblast
Dohad
Blastocyst
Endomètre
Adult
Développement embryonnaire
Equine
Développement
Gene expression
BIOLOGIE DU DEVELOPPEMENT
IMAGE
Epigénétique
Reproduction
Fertility
Lapin
Somatic cell nuclear transfer
Foetus
Jument
Chromatin
Souris
Ovaire
PLACENTA
Embryo development
Épigénétique
Obésité
EMBRYO
Poulain
Bovine
Goat
Rabbit
NUCLEAR TRANSFER
Pluripotency
GENOMIQUE
Embryo
Oocyte
Nutrition
Bovin
GENETIQUE
Spermatogenesis
Animal model
Epigenetic
Embryo transfer
Humans
Cow
Foxl2
Implantation
Méthylation
Sexual dimorphism
Epigenetics
Meiosis
Programming
Mouse
Conceptus
Fertilité
Methylation
Alimentation
Sperm
Phénotype
Sheep
Ovary
BIOTECHNOLOGIE
Environment
Animal models
Ruminant
These
Horse
Uterus
Métabolisme
Progesterone
RAT
Gestation
Male
Development
Female
Endometrium
Mice
Nuclear transfer
Animal modèle
Chorion
IMMUNOLOGIE
Placenta
Fetal programming
Programmation foetale
Embryon
Cattle
Dairy cow
Mare
Pregnancy
Oxidative stress
IMAGERIE
Cheval
DNA methylation
Sex determination
Obesity
Mammary gland
Transcriptome
Growth
Diesel