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Welcome to the BREED publications collection
The Biology of Reproduction, Environment, Epigenetics and Development (BREED) joint research unit studies the effects of environment, in the broadest sense, on reproduction, development during embryonic and foetal life and the health of offspring. It gathers researchers, hospital clinicians and veterinarians for both agronomic and biomedical research.
The scientific context is based on the need to understand and control the mechanisms of epigenetic programming during prenatal life leading to the birth of a healthy, fertile and robust individual, capable of adapting to changes in its environment.
The aims of our research are to improve fertility and the efficiency of reproductive biotechnologies in humans and animals, to study the physiological and molecular mechanisms that determine the phenotypes of the offspring (health, growth, fertility, etc.) and to identify predictive and non-invasive biomarkers for these phenotypes, some of which could complement genetic selection strategies in animals. The unit relies on research involving several animal models (rabbits, ruminants, rodents, horses) and multiple and complementary imaging approaches, from the microscopic scale to the whole live animal. In vitro models are also developed as alternatives to animal experimentation (primary cell cultures, organoids, embryoids). This expertise and tools are complemented by clinical studies conducted by hospital and veterinary practitioners.
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Ophélie Téteau, Anaïs Vitorino Carvalho, Pascal Papillier, Béatrice Mandon-Pepin, Luc Jouneau, et al.. Bisphenol A and bisphenol S both disrupt ovine granulosa cell steroidogenesis but through different molecular pathways. Journal of Ovarian Research, 2023, 16 (1), pp.30. ⟨10.1186/s13048-023-01114-4⟩. ⟨hal-03972669⟩
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Eva Bongaerts, Tim S Nawrot, Congrong Wang, Marcel Ameloot, Hannelore Bové, et al.. Placental-fetal distribution of carbon particles in a pregnant rabbit model after repeated exposure to diluted diesel engine exhaust. Particle and Fibre Toxicology, 2023, 20, ⟨10.1186/s12989-023-00531-z⟩. ⟨hal-04107365⟩
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Sara El Fouikar, Véronique Duranthon, Virginie Helies, Hélène Jammes, Anne Couturier-Tarrade, et al.. Multigenerational Effects of a Complex Human-Relevant Exposure during Folliculogenesis and Preimplantation Embryo Development: The FEDEXPO Study. Toxics, 2023, 11 (5), pp.425. ⟨10.3390/toxics11050425⟩. ⟨hal-04112370⟩
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Bérangère Coutanceau, Esther dos Santos, Nelly Swierkowski Blanchard, Anne Sanchez Louboutin, Florence Boitrelle, et al.. Should the Treatment of Patients with Repeated Embryo Implantation Failure Be Adapted as a Function of the Endometrial Cytokine Profile? A Single-Center Experience. Biomedicines, 2023, 11 (3), pp.817. ⟨10.3390/biomedicines11030817⟩. ⟨hal-04056031⟩
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Sylvie Chastant, Gary England, Oliver Forman, Alexander German, Jan Suchodolski, et al.. Environmental risk factors in puppies and kittens for developing chronic disorders in adulthood: A call for research on developmental programming. Frontiers in Veterinary Science, 2022, 9, ⟨10.3389/fvets.2022.944821⟩. ⟨hal-03912284⟩
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N. Gafsi, F. Bidan, Bénédicte Grimard, M. Legris, O. Martin, et al.. Relationships between fertility after artificial insemination, milk production dynamics, body reserves and heat stress in Alpine dairy goats. 26. Rencontres autour des Recherches sur les Ruminants (3R 2022), INRAE; IDELE, Dec 2022, Paris, France. pp.372-376. ⟨hal-04039512⟩
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Romina Via y Rada, Nathalie Daniel, Catherine Archilla, Anne Frambourg, Luc Jouneau, et al.. Identification of the Inner Cell Mass and the Trophectoderm Responses after an In Vitro Exposure to Glucose and Insulin during the Preimplantation Period in the Rabbit Embryo. Cells, 2022, 11 (23), pp. 3766. ⟨10.3390/cells11233766⟩. ⟨hal-03871680⟩
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Marion Bendayan, Emine Sais, Laura Alter, Khadija Fathallah, Monique Jaoul, et al.. For patients with non-obstructive azoospermia, the outcome of testicular sperm extraction correlates with self-esteem, sexual health and the quality of the couple’s relationship. Basic and clinical andrology, 2022, 32 (1), pp.3. ⟨10.1186/s12610-022-00153-z⟩. ⟨hal-03599599⟩
References
2 131
Open Access
32 %
Keywords
Epigenetics
Spermatogenesis
Méthylation
Female
BIOLOGIE DU DEVELOPPEMENT
Développement embryonnaire
Bovin
Sperm
RAT
Endomètre
Implantation
EMBRYO
Epigénétique
Lapin
Pluripotency
DOHaD
Nuclear transfer
Foetus
Gestation
Horse
Épigénétique
Animal modèle
Programmation foetale
Embryon
Uterus
Chromatin
Development
Sex determination
Développement
Pregnancy
Fertility
Obesity
Embryo transfer
Fetal programming
GENOMIQUE
Obésité
Cheval
Diesel
Meiosis
DNA methylation
Foxl2
Cattle
Gene expression
Conceptus
Epigenetic
Poulain
Nutrition
Embryo development
IMMUNOLOGIE
Adult
Mammary gland
Cow
Methylation
Placenta
Phénotype
Dairy cow
Animal model
Mice
Rabbit
Progesterone
Ovary
Blastocyst
Somatic cell nuclear transfer
Alimentation
NUCLEAR TRANSFER
Oxidative stress
Fertilité
Mouse
Programming
PLACENTA
IMAGERIE
Animal models
Dohad
Reproduction
Ovaire
Sexual dimorphism
Goat
Dna methylation
IMAGE
Souris
Environment
Transcriptome
Humans
Male
Sheep
Jument
Ruminant
Chorion
Endometrium
BIOTECHNOLOGIE
Embryo
Mare
Oocyte
Métabolisme
Equine
Trophoblast
GENETIQUE
Growth
Bovine
These