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Welcome to the BREED publications collection
The Biology of Reproduction, Environment, Epigenetics and Development (BREED) joint research unit studies the effects of environment, in the broadest sense, on reproduction, development during embryonic and foetal life and the health of offspring. It gathers researchers, hospital clinicians and veterinarians for both agronomic and biomedical research.
The scientific context is based on the need to understand and control the mechanisms of epigenetic programming during prenatal life leading to the birth of a healthy, fertile and robust individual, capable of adapting to changes in its environment.
The aims of our research are to improve fertility and the efficiency of reproductive biotechnologies in humans and animals, to study the physiological and molecular mechanisms that determine the phenotypes of the offspring (health, growth, fertility, etc.) and to identify predictive and non-invasive biomarkers for these phenotypes, some of which could complement genetic selection strategies in animals. The unit relies on research involving several animal models (rabbits, ruminants, rodents, horses) and multiple and complementary imaging approaches, from the microscopic scale to the whole live animal. In vitro models are also developed as alternatives to animal experimentation (primary cell cultures, organoids, embryoids). This expertise and tools are complemented by clinical studies conducted by hospital and veterinary practitioners.
Last additions
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Ophélie Téteau, Anaïs Vitorino Carvalho, Pascal Papillier, Béatrice Mandon-Pepin, Luc Jouneau, et al.. Bisphenol A and bisphenol S both disrupt ovine granulosa cell steroidogenesis but through different molecular pathways. Journal of Ovarian Research, 2023, 16 (1), pp.30. ⟨10.1186/s13048-023-01114-4⟩. ⟨hal-03972669⟩
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Eva Bongaerts, Tim S Nawrot, Congrong Wang, Marcel Ameloot, Hannelore Bové, et al.. Placental-fetal distribution of carbon particles in a pregnant rabbit model after repeated exposure to diluted diesel engine exhaust. Particle and Fibre Toxicology, 2023, 20, ⟨10.1186/s12989-023-00531-z⟩. ⟨hal-04107365⟩
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Eva Bongaerts, Tim S Nawrot, Congrong Wang, Marcel Ameloot, Hannelore Bové, et al.. Placental-fetal distribution of carbon particles in a pregnant rabbit model after repeated exposure to diluted diesel engine exhaust. Particle and Fibre Toxicology, 2023, 20, ⟨10.1186/s12989-023-00531-z⟩. ⟨hal-04106052⟩
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Sara El Fouikar, Véronique Duranthon, Virginie Helies, Hélène Jammes, Anne Couturier-Tarrade, et al.. Multigenerational Effects of a Complex Human-Relevant Exposure during Folliculogenesis and Preimplantation Embryo Development: The FEDEXPO Study. Toxics, 2023, 11 (5), pp.425. ⟨10.3390/toxics11050425⟩. ⟨hal-04112370⟩
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Bérangère Coutanceau, Esther dos Santos, Nelly Swierkowski Blanchard, Anne Sanchez Louboutin, Florence Boitrelle, et al.. Should the Treatment of Patients with Repeated Embryo Implantation Failure Be Adapted as a Function of the Endometrial Cytokine Profile? A Single-Center Experience. Biomedicines, 2023, 11 (3), pp.817. ⟨10.3390/biomedicines11030817⟩. ⟨hal-04056031⟩
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Sylvie Chastant, Gary England, Oliver Forman, Alexander German, Jan Suchodolski, et al.. Environmental risk factors in puppies and kittens for developing chronic disorders in adulthood: A call for research on developmental programming. Frontiers in Veterinary Science, 2022, 9, ⟨10.3389/fvets.2022.944821⟩. ⟨hal-03912284⟩
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N. Gafsi, F. Bidan, Bénédicte Grimard, M. Legris, O. Martin, et al.. Relationships between fertility after artificial insemination, milk production dynamics, body reserves and heat stress in Alpine dairy goats. 26. Rencontres autour des Recherches sur les Ruminants (3R 2022), INRAE; IDELE, Dec 2022, Paris, France. pp.372-376. ⟨hal-04039512⟩
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Romina Via y Rada, Nathalie Daniel, Catherine Archilla, Anne Frambourg, Luc Jouneau, et al.. Identification of the Inner Cell Mass and the Trophectoderm Responses after an In Vitro Exposure to Glucose and Insulin during the Preimplantation Period in the Rabbit Embryo. Cells, 2022, 11 (23), pp. 3766. ⟨10.3390/cells11233766⟩. ⟨hal-03871680⟩
References
2 131
Open Access
32 %
Keywords
Programmation foetale
Jument
Animal models
Embryo
Reproduction
IMAGERIE
Epigenetics
Rabbit
Animal modèle
Phénotype
Lapin
Progesterone
IMMUNOLOGIE
Methylation
Female
Mouse
Obesity
Embryon
PLACENTA
Oxidative stress
GENOMIQUE
Male
Chorion
Mare
Programming
Ovaire
Trophoblast
Gene expression
Uterus
Sheep
Sex determination
Adult
DOHaD
Foxl2
Cattle
BIOTECHNOLOGIE
IMAGE
Gestation
Méthylation
Diesel
Obésité
Epigénétique
These
Sperm
DNA methylation
Endometrium
BIOLOGIE DU DEVELOPPEMENT
Foetus
Alimentation
Growth
Humans
Meiosis
Souris
Fertilité
Pluripotency
Cheval
Pregnancy
Animal model
Goat
Cow
Fetal programming
Poulain
Nutrition
Transcriptome
Placenta
EMBRYO
Bovin
Métabolisme
Oocyte
Embryo development
Développement embryonnaire
Development
Dohad
Endomètre
Epigenetic
Développement
NUCLEAR TRANSFER
Embryo transfer
Nuclear transfer
Dairy cow
GENETIQUE
Implantation
Environment
Ruminant
Bovine
Chromatin
Mice
Fertility
Ovary
Dna methylation
Sexual dimorphism
Conceptus
Épigénétique
Blastocyst
Somatic cell nuclear transfer
Horse
Spermatogenesis
RAT
Mammary gland
Equine