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Welcome to the BREED publications collection
The Biology of Reproduction, Environment, Epigenetics and Development (BREED) joint research unit studies the effects of environment, in the broadest sense, on reproduction, development during embryonic and foetal life and the health of offspring. It gathers researchers, hospital clinicians and veterinarians for both agronomic and biomedical research.
The scientific context is based on the need to understand and control the mechanisms of epigenetic programming during prenatal life leading to the birth of a healthy, fertile and robust individual, capable of adapting to changes in its environment.
The aims of our research are to improve fertility and the efficiency of reproductive biotechnologies in humans and animals, to study the physiological and molecular mechanisms that determine the phenotypes of the offspring (health, growth, fertility, etc.) and to identify predictive and non-invasive biomarkers for these phenotypes, some of which could complement genetic selection strategies in animals. The unit relies on research involving several animal models (rabbits, ruminants, rodents, horses) and multiple and complementary imaging approaches, from the microscopic scale to the whole live animal. In vitro models are also developed as alternatives to animal experimentation (primary cell cultures, organoids, embryoids). This expertise and tools are complemented by clinical studies conducted by hospital and veterinary practitioners.
Last additions
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Dorothee Ledoux, Isabelle Veissier, Bruno Meunier, Valerie Gelin, Christophe Richard, et al.. Combining accelerometers and direct visual observations to detect sickness and pain in cows of different ages submitted to systemic inflammation. Scientific Reports, 2023, 13 (1), pp.1977. ⟨10.1038/s41598-023-27884-x⟩. ⟨hal-03975769⟩
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Ophélie Téteau, Anaïs Vitorino Carvalho, Pascal Papillier, Béatrice Mandon-Pepin, Luc Jouneau, et al.. Bisphenol A and bisphenol S both disrupt ovine granulosa cell steroidogenesis but through different molecular pathways. Journal of Ovarian Research, 2023, 16 (1), pp.30. ⟨10.1186/s13048-023-01114-4⟩. ⟨hal-03972669⟩
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Mariana Mescouto Lopes, Caroline Clouard, Jennifer Chambeaud, Manon Brien, Nicolas Villain, et al.. Impact of environmental enrichment on the behaviour and immune cell transcriptome of pregnant sows. 74. Annual meeting of the european federation of animal science (EAAP), INRAE; EAAP, Aug 2023, Lyon, France. pp.887. ⟨hal-04207105⟩
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Laurent Galio, Laetitia Bernet, Yoann Rodriguez, Camille Fourcault, Marie‐noëlle Dieudonné, et al.. The effect of obesity on uterine receptivity is mediated by endometrial extracellular vesicles that control human endometrial stromal cell decidualization and trophoblast invasion. Journal of Extracellular Biology, 2023, 2 (7), ⟨10.1002/jex2.103⟩. ⟨hal-04165774⟩
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Rossella Cannarella, Rupin Shah, Taha Abo-Almagd Abdel-Meguid Hamoda, Florence Boitrelle, Ramadan Saleh, et al.. Does Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study of Before-After Data. The World Journal of Men's Health, 2023, 41, ⟨10.5534/wjmh.230034⟩. ⟨hal-04149299⟩
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References
2 155
Open Access
32 %
Keywords
DNA methylation
Trophoblast
Gestation
Epigénétique
Méthylation
Fertilité
Nutrition
Endomètre
NUCLEAR TRANSFER
Reproduction
Horse
GENETIQUE
Bovin
Ovaire
Ovary
Embryo
Humans
Fertility
Animal modèle
Growth
Nuclear transfer
IMMUNOLOGIE
Infertility
Epigenetic
DOHaD
Rabbit
Somatic cell nuclear transfer
Conceptus
Female
Mammary gland
Uterus
Embryon
Meiosis
Pregnancy
Pluripotency
Foxl2
IMAGERIE
Cheval
Lapin
Adult
Alimentation
Obesity
Animal model
Souris
Sex determination
RAT
Fetal programming
Environment
IMAGE
Développement
Goat
Diesel
Male
Cattle
Sheep
Phénotype
Dna methylation
Development
Chorion
Male infertility
Equine
Gene expression
Mare
BIOTECHNOLOGIE
Spermatogenesis
Développement embryonnaire
Animal models
Poulain
Methylation
Placenta
Programming
PLACENTA
Endometrium
GENOMIQUE
Dairy cow
Bovine
Ruminant
Implantation
Jument
Mice
Métabolisme
Dohad
Sperm
Foetus
Embryo transfer
EMBRYO
Programmation foetale
These
Progesterone
Epigenetics
BIOLOGIE DU DEVELOPPEMENT
Oxidative stress
Oocyte
Transcriptome
Sexual dimorphism
Mouse
Obésité
Embryo development
Blastocyst
Épigénétique