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Welcome to the BREED publications collection
The Biology of Reproduction, Environment, Epigenetics and Development (BREED) joint research unit studies the effects of environment, in the broadest sense, on reproduction, development during embryonic and foetal life and the health of offspring. It gathers researchers, hospital clinicians and veterinarians for both agronomic and biomedical research.
The scientific context is based on the need to understand and control the mechanisms of epigenetic programming during prenatal life leading to the birth of a healthy, fertile and robust individual, capable of adapting to changes in its environment.
The aims of our research are to improve fertility and the efficiency of reproductive biotechnologies in humans and animals, to study the physiological and molecular mechanisms that determine the phenotypes of the offspring (health, growth, fertility, etc.) and to identify predictive and non-invasive biomarkers for these phenotypes, some of which could complement genetic selection strategies in animals. The unit relies on research involving several animal models (rabbits, ruminants, rodents, horses) and multiple and complementary imaging approaches, from the microscopic scale to the whole live animal. In vitro models are also developed as alternatives to animal experimentation (primary cell cultures, organoids, embryoids). This expertise and tools are complemented by clinical studies conducted by hospital and veterinary practitioners.
Last additions
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Dorothee Ledoux, Isabelle Veissier, Bruno Meunier, Valerie Gelin, Christophe Richard, et al.. Combining accelerometers and direct visual observations to detect sickness and pain in cows of different ages submitted to systemic inflammation. Scientific Reports, 2023, 13 (1), pp.1977. ⟨10.1038/s41598-023-27884-x⟩. ⟨hal-03975769⟩
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Ophélie Téteau, Anaïs Vitorino Carvalho, Pascal Papillier, Béatrice Mandon-Pepin, Luc Jouneau, et al.. Bisphenol A and bisphenol S both disrupt ovine granulosa cell steroidogenesis but through different molecular pathways. Journal of Ovarian Research, 2023, 16 (1), pp.30. ⟨10.1186/s13048-023-01114-4⟩. ⟨hal-03972669⟩
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Mariana Mescouto Lopes, Caroline Clouard, Jennifer Chambeaud, Manon Brien, Nicolas Villain, et al.. Impact of environmental enrichment on the behaviour and immune cell transcriptome of pregnant sows. 74. Annual meeting of the european federation of animal science (EAAP), INRAE; EAAP, Aug 2023, Lyon, France. pp.887. ⟨hal-04207105⟩
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Laurent Galio, Laetitia Bernet, Yoann Rodriguez, Camille Fourcault, Marie‐noëlle Dieudonné, et al.. The effect of obesity on uterine receptivity is mediated by endometrial extracellular vesicles that control human endometrial stromal cell decidualization and trophoblast invasion. Journal of Extracellular Biology, 2023, 2 (7), ⟨10.1002/jex2.103⟩. ⟨hal-04165774⟩
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Rossella Cannarella, Rupin Shah, Taha Abo-Almagd Abdel-Meguid Hamoda, Florence Boitrelle, Ramadan Saleh, et al.. Does Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study of Before-After Data. The World Journal of Men's Health, 2023, 41, ⟨10.5534/wjmh.230034⟩. ⟨hal-04149299⟩
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Mahendra Mariadassou, Laurent-Xavier Nouvel, Fabienne Constant, Diego P. Morgavi, Lucie Rault, et al.. Microbiota members from body sites of dairy cows are largely shared within individual hosts throughout lactation but sharing is limited in the herd. Animal Microbiome, 2023, 5 (1), pp.32. ⟨10.1186/s42523-023-00252-w⟩. ⟨hal-04126196⟩
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E. Ivanova, Catherine Hue-Beauvais, Aurélie Chaulot-Talmon, J. Castille, J Laubier, et al.. DNA methylation and gene expression changes in mouse mammary tissue during successive lactations: part I – the impact of inflammation. Epigenetics, 2023, 18 (1), ⟨10.1080/15592294.2023.2215633⟩. ⟨hal-04127637⟩
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References
2 156
Open Access
32 %
Keywords
Development
Mouse
Sperm
Spermatogenesis
Infertility
Cheval
Cattle
Embryon
Meiosis
Poulain
Programmation foetale
Rabbit
BIOTECHNOLOGIE
Embryo development
Fertilité
IMAGERIE
Environment
Uterus
Diesel
Somatic cell nuclear transfer
Lapin
Horse
Développement
Obésité
NUCLEAR TRANSFER
IMAGE
Animal model
Méthylation
Male infertility
Pregnancy
Chorion
Epigénétique
Animal modèle
Mice
Fetal programming
Gestation
Dairy cow
Pluripotency
Equine
Foxl2
Souris
Placenta
These
Female
Métabolisme
Sheep
Nutrition
Oxidative stress
Oocyte
Obesity
Animal models
Growth
Alimentation
EMBRYO
Ruminant
RAT
Endometrium
Sexual dimorphism
Humans
BIOLOGIE DU DEVELOPPEMENT
Jument
Methylation
Fertility
Programming
Male
Bovin
PLACENTA
Conceptus
GENETIQUE
Mare
Épigénétique
Transcriptome
GENOMIQUE
Endomètre
Foetus
Epigenetic
Phénotype
Reproduction
Epigenetics
DOHaD
Gene expression
DNA methylation
Développement embryonnaire
Mammary gland
Embryo
Nuclear transfer
Sex determination
Progesterone
Ovaire
IMMUNOLOGIE
Ovary
Implantation
Dna methylation
Goat
Blastocyst
Dohad
Embryo transfer
Trophoblast
Bovine
Adult