Synthesis of β-CF3 ketones from trifluoromethylated allylic alcohols by ruthenium catalyzed isomerization - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Fluorine Chemistry Année : 2013

Synthesis of β-CF3 ketones from trifluoromethylated allylic alcohols by ruthenium catalyzed isomerization

Résumé

This work describes the optimization process for the synthesis of β-trifluoromethylated ketones from trifluoromethylated allylic alcohols. This transformation proceeds through a ruthenium catalyzed isomerization under mild conditions with high atom economy. The effect of the CF3 group was analyzed and it provides fundamental insights into the isomerization reaction.

Domaines

Chimie organique

Dates et versions

hal-01015319 , version 1 (26-06-2014)

Identifiants

Citer

Vincent Bizet, Xavier Pannecoucke, Jean-Luc Renaud, Dominique Cahard. Synthesis of β-CF3 ketones from trifluoromethylated allylic alcohols by ruthenium catalyzed isomerization. Journal of Fluorine Chemistry, 2013, 152, pp.56-61. ⟨10.1016/j.jfluchem.2013.01.004⟩. ⟨hal-01015319⟩
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