Article Dans Une Revue Journal of Fluorine Chemistry Année : 2013

Synthesis of β-CF3 ketones from trifluoromethylated allylic alcohols by ruthenium catalyzed isomerization

Résumé

This work describes the optimization process for the synthesis of β-trifluoromethylated ketones from trifluoromethylated allylic alcohols. This transformation proceeds through a ruthenium catalyzed isomerization under mild conditions with high atom economy. The effect of the CF3 group was analyzed and it provides fundamental insights into the isomerization reaction.

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hal-01015319 , version 1 (26-06-2014)

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Vincent Bizet, Xavier Pannecoucke, Jean-Luc Renaud, Dominique Cahard. Synthesis of β-CF3 ketones from trifluoromethylated allylic alcohols by ruthenium catalyzed isomerization. Journal of Fluorine Chemistry, 2013, 152, pp.56-61. ⟨10.1016/j.jfluchem.2013.01.004⟩. ⟨hal-01015319⟩
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