Auxin-Binding Protein 1 is a negative regulator of the SCF(TIR1/AFB) pathway - Archive ouverte HAL
Journal Articles Nature Communications Year : 2013

Auxin-Binding Protein 1 is a negative regulator of the SCF(TIR1/AFB) pathway

Abstract

Auxin is a major plant hormone that controls most aspects of plant growth and development. Auxin is perceived by two distinct classes of receptors: transport inhibitor response 1 (TIR1, or auxin-related F-box (AFB)) and auxin/indole-3-acetic acid (AUX/IAA) coreceptors, that control transcriptional responses to auxin, and the auxin-binding protein 1 (ABP1), that controls a wide variety of growth and developmental processes. To date, the mode of action of ABP1 is still poorly understood and its functional interaction with TIR1/AFB-AUX/IAA coreceptors remains elusive. Here we combine genetic and biochemical approaches to gain insight into the integration of these two pathways. We find that ABP1 is genetically upstream of TIR1/AFBs; ABP1 knockdown leads to an enhanced degradation of AUX/IAA repressors, independently of its effects on endocytosis, through the SCF TIR1/AFB E3 ubiquitin ligase pathway. Combining positive and negative regulation of SCF ubiquitin-dependent pathways might be a common mechanism conferring tight control of hormone-mediated responses.

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Dates and versions

hal-00939402 , version 1 (07-01-2020)

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A. Tromas, S. Paque, V. Stierlé, A.L. Quettier, P. Muller, et al.. Auxin-Binding Protein 1 is a negative regulator of the SCF(TIR1/AFB) pathway. Nature Communications, 2013, 13 (4), pp.2496. ⟨10.1038/ncomms3496⟩. ⟨hal-00939402⟩
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