Generalized Lorenz-Mie Theory (GLMT) for a multilayered sphere is used to simulate holograms produced by evaporating spherical droplets with refractive index gradient in the surrounding air/vapor mixture. Simulated holograms provide a physical interpretation of experimental holograms produced by evaporating Diethyl Ether droplets with diameter in the order of 50 μm and recorded in a digital in-line holography configuration with a divergent beam. Refractive index gradients in the surrounding medium lead to a modification of the center part of the droplet holograms, where the first fringe is unusually bright. GLMT simulations reproduce well this modification, assuming an exponential decay of the refractive index from the droplet surface to infinity. The diverging beam effect is also considered. In both evaporating and non evaporating cases, an equivalence is found between Gaussian beam and plane wave illuminations, simply based on a magnification ratio to be applied to the droplets' parameters.