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Article Dans Une Revue Journal of Physical Chemistry C Année : 2013

X-ray-Induced singlet oxygen activation with nanoscintillator-coupled porphyrins

Résumé

Tb2O3 coated with a polysiloxane layer is a biocompatible nanoscintillator that exhibits an appropriate pattern of biodistribution after injection. In this contribution, we combine this nanosystem with porphyrin molecules that are able to generate singlet oxygen, a major cytotoxic agent for photodynamic therapy application. Using time-resolved laser spectroscopy and singlet oxygen probes, we demonstrate this combination is suitable for singlet oxygen generation induced by X-ray and provide a physical study of the energy transfer observed between the nanoscintillator and the porphyrin. Combined with a radiotherapy protocol, the proposed nanohybrid system presents a combination of physical, chemical, and biological properties that make it a good candidate for photodynamic effects in deep tissues.
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Dates et versions

hal-00907860 , version 1 (21-11-2013)

Identifiants

Citer

Anne-Laure Bulin, Charles Truillet, Rima Chouikrat, François Lux, Céline Frochot, et al.. X-ray-Induced singlet oxygen activation with nanoscintillator-coupled porphyrins. Journal of Physical Chemistry C, 2013, 117 (41), pp.21583-21589. ⟨10.1021/jp4077189⟩. ⟨hal-00907860⟩
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