Accurate flood forecasts are critical to an efficient flood event management strategy. Until now, hydro-meteorological forecasts have mainly been used to establish early-warnings in France (meteorological and flood vigilance maps) or over the world (flash-flood guidances). These forecasts are typically limited either to the main streams covered by the flood forecasting services or to specific watersheds with specific assets like check dams, which in most cases are well gauged river sections, thus leaving aside large parts of the territory. This paper presents a distributed hydro-meteorological forecasting approach, which makes use of the high spatial and temporal resolution rainfall estimates that are now available, to provide information at ungauged sites. The proposed system intended to detect road inundation risks had initially been developed and tested in areas of limited size. This paper presents the extension of such a system to an entire region (i.e. the Gard region in Southern France), including over 2,000 crossing points between rivers and roads and its validation with respect to a large data set of actual reported road inundations observed during recent flash flood events. These initial validation results appear to be most promising. The eventual proposed tool would provide the necessary information for flood event management services to identify the areas at risk and adopt appropriate safety and rescue measures: i.e. pre-positioning of rescue equipment, interruption of the traffic on the exposed roads and determination of safe access or evacuation routes. Moreover, beyond the specific application to the supervision of a road network, the research undertaken herein also provides also results for the performance of hydro-meteorological forecasts on ungauged headwaters.