The introduction of distance learning does not only bring a wider audience, but also much more diversity among the learners: first, because it can be integrated more easily into a Life-long Learning strategy; secondly, because the learners are not restricted to a sing le area and thus learners from different countries and with different cultures follow the curriculum. We have observed this in various DL diplomas in which we participate. In this article, we will shed some light on the difficulties and challenges arising from these multi-cultural settings. Based on our research work, we would like to insist on two particular points which are the necessity to adapt the pedagogical settings (e.g. pedagogical scenarios) according to the learners' behaviour to overcome unforeseen problems due to cultural differences and the importance of considering mobile technologies to overcome limited access to the technology in developing countries and to ensure continuous interaction among learners and with tutors.