Large-eddy simulations of a generic turbulent flow with discrete effusion are reported. The computational domain is periodic in both streamwise and spanwise directions and contains both the injection and the suction sides. The blowing ratio is close to 1.2 while the Reynolds number in the aperture is of order 2600. The numerical results for this fully developed bi-periodic turbulent flow with effusion are compared to available experimental data from a large-scale spatially evolving isothermal configuration. It is shown that many features are shared by the two flow configurations. The main difference is related to the mean streamwise velocity profile, which is more flat for the bi-periodic situation where the cumulative effect of an infinite number of upstream jets is accounted for. The necessity of considering both sides of the plate is also established by analysing the vortical structure of the flow and some differences with the classical jet-in-crossflow case are highlighted. Finally, the numerical results are analysed in terms of wall modelling for full-coverage film cooling. For the operating point considered, it is demonstrated that the streamwise momentum flux is dominated by non-viscous effects, although the area where only the viscous shear stress contributes is very large given the small porosity value (4%).