The loss or gain of certain host species may either dilute or amplify the risk of pathogen and parasite infection through direct or indirect effects. The relative contribution of host communities combined with climate and landscape characteristics on non-vector-borne parasite transmission to humans has been a relatively neglected area of investigation. Based on a case study, we explore how landscape epidemiology and landscape ecology can contribute to better understand spatial and temporal processes of pathogen dynamics. Research carried out in different intermediate host communities of Western Europe and continental China indicate more intensive zoonotic transmission of the cestode E. multilocularis in homogeneous landscapes with larger areas of optimal habitats for one or some host species in low diversity small mammal communities, making multi-annual population outbreaks more likely. Those results support the notion that landscape, small mammal host diversity and their population dynamics alter prey - predator relationships and associated host/parasite transmission, hence modify the transmission of endemic infections. Here, landscape and biodiversity may protect humans from zoonotic parasite transmission where they prevent population outbreaks of a few specific small mammal host species. Most landscapes, e.g. changing mosaics of habitats and communities, are anthropogenic and characterized by various degrees of habitat fragmentation with emergent properties. Those spatial configurations have direct and indirect effects on ecological processes, and may cause a cascade of factors that exacerbate or slow down the spread of pathogens. Retrospective analyses strongly suggest that increased transmission of E. multilocularis in the Jura massif, eastern France, and in China, even though habitats and species are different, originate from anthropogenic landscape alterations. Encouraged by the European agriculture common policy, farmers in the Doubs department, France, specialized in milk/cheese production in the 1960s and converted most ploughed fields into permanent grassland in mountain areas. With the destruction of hedges, this shifted the regional systems towards a more highly productive agriculture and triggered large scale small mammal outbreaks with a cascade of consequences in agriculture, biological conservation and public health. In China, similar effects came from deforestation and agriculture encroachments during the 1980s, extending areas favourable to small mammal intermediate host species prone to multiannual population outbreaks. This strongly suggests that functional invariants are at stake whatever the ecosystems, and that the impacts of landscape on community processes and population dynamics interfere with disease regulation and lead to more or less "healthy" landscapes. In such a context, disease regulation cannot be contemplated alone. It should be considered in a systems approach and taken into account together with other associated issues such as biodiversity, landscape management, small mammal pest control, conservation of protected species, game management, etc. Following Patz et al. (2004), we believe that strong transdisciplinary research partnerships need to be forged to approach the research with the degree of creative thinking and comprehensiveness required by the nature of those system issues. Investigators must consider how they can integrate their findings into the social, economic, and political dialogue on both the ecosystems and health, globally and locally.