One of the greatest challenges in Ambient Assisted Living is to design health smart homes that anticipate the needs of its inhabitant while maintaining their safety and comfort. It is thus essential to ease the interaction with the smart home through systems that naturally react to voice command using microphones rather than tactile interfaces. However, efficient audio analysis in such noisy environment is a challenging task. In this paper, a real-time audio analysis system, the AuditHIS system, devoted to audio analysis in smart home environment is presented. AuditHIS has been tested thought three experiments carried out in a smart home that are detailed. The results show the difficulty of the task and serve as basis to discuss the stakes and the challenges of this promising technology in the domain of AAL.