Analysis of short-term deformation along the southern part of Dead Sea Fault (DSF) provides a systematic view of kinematics this part of the continental transform. The southern DSF consists of two principal segments: the Wadi Araba and Jordan Valley faults. In addition to other regional continuous GPS data, this study uses new data from 25 survey sites and 4 continuous GPS stations in Jordan for improved near-field observations. Resulting velocities are reported with 1-sigma uncertainties ranging from 0.4-1.0 mm/yr. Application of elastic dislocation models yields estimates of slip rates for Wadi Araba and Jordan Valley faults are 4.9 +/- 0.4 mm/yr and 4.7 +/- 0.4 mm/yr, respectively. Modeling also suggests different depths of effective fault locking with 15 +/- 5 km and 8 +/- 5 km for the Wadi Araba and Jordan Valley faults, respectively. These slip rates are generally consistent with the upper end of the range of slip rates estimated from late Quaternary geology. Spatial variations in effective fault locking generally correspond with a heterogeneous mantle lithosphere. A similar observation can be observed along the southern San Andreas Fault, and this may reflect the influence of heterogeneity in the uppermost mantle on crustal faulting processes.