The objective of this chapter is to present advanced control methodologies of uncertain nonlinear systems. Firstly, adaptive sliding mode controller that retains the system's robustness in the presence of the bounded uncertainties/perturbations with unknown bounds is proposed. Due to the on-line adaptation, the proposed approach allows reducing control chattering. Secondly, a high order sliding mode control strategy that features a priory knowledge of the convergence time is presented. Finally, the output feedback second order sliding mode controller is presented and discussed. The control algorithms are applied to experimental set-up equipped by electrical or electropneumatic actuators.