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Article Dans Une Revue Bioorganic and Medicinal Chemistry Letters Année : 2010

Straightforward synthesis of triazoloacylonucleotide phosphonates as potential HCV inhibitors

Résumé

Preparation of several triazoloacyclic nucleoside phosphonates is described. The key step of the synthesis involves a copper(I)-catalysed azide-alkyne 1,3-dipolar cycloaddition between azidoalkylphosphonates and propargylated nucleobases. The antiviral properties of these new analogues have been evaluated and revealed interesting potencies.

Domaines

Chimie organique

Dates et versions

hal-00616738 , version 1 (24-08-2011)

Identifiants

Citer

Hanane Elayadi, Michael Smietana, Christophe Pannecouque, Pieter Leyssen, Johan Neyts, et al.. Straightforward synthesis of triazoloacylonucleotide phosphonates as potential HCV inhibitors. Bioorganic and Medicinal Chemistry Letters, 2010, 20, pp.7365-7368. ⟨10.1016/j.bmcl.2010.10.046⟩. ⟨hal-00616738⟩
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