Straightforward synthesis of triazoloacylonucleotide phosphonates as potential HCV inhibitors

Preparation of several triazoloacyclic nucleoside phosphonates is described. The key step of the synthesis involves a copper(I)-catalysed azide-alkyne 1,3-dipolar cycloaddition between azidoalkylphosphonates and propargylated nucleobases. The antiviral properties of these new analogues have been evaluated and revealed interesting potencies.

Mots clés

antiviral click chemistry nucleotides analogues HCV

Domaines

Chimie organique

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https://hal.science/hal-00616738

Soumis le : mercredi 24 août 2011-10:37:10

Dernière modification le : mercredi 4 décembre 2024-10:20:03

Dates et versions

hal-00616738 , version 1 (24-08-2011)

Identifiants

HAL Id : hal-00616738 , version 1
DOI : 10.1016/j.bmcl.2010.10.046

Citer

Hanane Elayadi, Michael Smietana, Christophe Pannecouque, Pieter Leyssen, Johan Neyts, et al.. Straightforward synthesis of triazoloacylonucleotide phosphonates as potential HCV inhibitors. Bioorganic and Medicinal Chemistry Letters, 2010, 20, pp.7365-7368. ⟨10.1016/j.bmcl.2010.10.046⟩. ⟨hal-00616738⟩

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