Luminescence targeting and imaging using a nanoscale generation 3 dendrimer in an in vivo colorectal metastatic rat model. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Nanomedicine Année : 2011

Luminescence targeting and imaging using a nanoscale generation 3 dendrimer in an in vivo colorectal metastatic rat model.

Marco A Alcala
  • Fonction : Auteur
Shu Ying Kwan
  • Fonction : Auteur
Chad M Shade
  • Fonction : Auteur
Megan Lang
  • Fonction : Auteur
Hyounsoo Uh
  • Fonction : Auteur
Manyan Wang
  • Fonction : Auteur
Stephen G Weber
  • Fonction : Auteur
David L Bartlett
  • Fonction : Auteur
Stéphane Petoud
Yong J Lee
  • Fonction : Auteur

Résumé

Surgery is currently the best approach for treating either primary or metastatic hepatic malignancies. Because only 20% of hepatic cancers are operable in patients, several types of regional therapy (RT) are emerging as alternate treatment modalities. However, RTs can have their own limitations at controlling tumor growth or may lack the ability to detect such metastases. Additional strategies can be implemented to enhance their efficacy. An animal model of hepatic metastases coupled with a gastroduodenal artery (GDA) cannulation technique may provide a site to apply such therapies. In our study, splenic injections were performed with CC531 adenocarcinoma cells, which generated metastatic hepatic tumors in WAG/RijHsd rats. Cannulation of GDA was achieved via a polyethylene catheter. Infusion of generation 3 polyamidoamine 4-amino-1,8-naphthalimide dendrimer containing 8 europium ions (Eu-G3P4A18N) via the GDA resulted in luminescence of the hepatic metastatic nodules. Imaging of the metastatic hepatic nodules was obtained with the help of a cooled charge coupled device (CCD) camera.

Dates et versions

hal-00591653 , version 1 (09-05-2011)

Identifiants

Citer

Marco A Alcala, Shu Ying Kwan, Chad M Shade, Megan Lang, Hyounsoo Uh, et al.. Luminescence targeting and imaging using a nanoscale generation 3 dendrimer in an in vivo colorectal metastatic rat model.. Nanomedicine, 2011, 7 (3), pp.249-258. ⟨10.1016/j.nano.2010.09.002⟩. ⟨hal-00591653⟩
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