Luminescence targeting and imaging using a nanoscale generation 3 dendrimer in an in vivo colorectal metastatic rat model. - Archive ouverte HAL Access content directly
Journal Articles Nanomedicine Year : 2011

Luminescence targeting and imaging using a nanoscale generation 3 dendrimer in an in vivo colorectal metastatic rat model.

Marco A Alcala
  • Function : Author
Shu Ying Kwan
  • Function : Author
Chad M Shade
  • Function : Author
Megan Lang
  • Function : Author
Hyounsoo Uh
  • Function : Author
Manyan Wang
  • Function : Author
Stephen G Weber
  • Function : Author
David L Bartlett
  • Function : Author
Stéphane Petoud
Yong J Lee
  • Function : Author

Abstract

Surgery is currently the best approach for treating either primary or metastatic hepatic malignancies. Because only 20% of hepatic cancers are operable in patients, several types of regional therapy (RT) are emerging as alternate treatment modalities. However, RTs can have their own limitations at controlling tumor growth or may lack the ability to detect such metastases. Additional strategies can be implemented to enhance their efficacy. An animal model of hepatic metastases coupled with a gastroduodenal artery (GDA) cannulation technique may provide a site to apply such therapies. In our study, splenic injections were performed with CC531 adenocarcinoma cells, which generated metastatic hepatic tumors in WAG/RijHsd rats. Cannulation of GDA was achieved via a polyethylene catheter. Infusion of generation 3 polyamidoamine 4-amino-1,8-naphthalimide dendrimer containing 8 europium ions (Eu-G3P4A18N) via the GDA resulted in luminescence of the hepatic metastatic nodules. Imaging of the metastatic hepatic nodules was obtained with the help of a cooled charge coupled device (CCD) camera.

Dates and versions

hal-00591653 , version 1 (09-05-2011)

Identifiers

Cite

Marco A Alcala, Shu Ying Kwan, Chad M Shade, Megan Lang, Hyounsoo Uh, et al.. Luminescence targeting and imaging using a nanoscale generation 3 dendrimer in an in vivo colorectal metastatic rat model.. Nanomedicine, 2011, 7 (3), pp.249-258. ⟨10.1016/j.nano.2010.09.002⟩. ⟨hal-00591653⟩
79 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More