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Article Dans Une Revue Journal of Materials Chemistry Année : 2010

Sol-gel selection of hybrid G-quadruplex architectures from dynamic supramolecular guanosine libraries

Simona Mihai
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Yann Le Duc
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Didier Cot

Résumé

We report an original strategy to transcribe and to fix the self-assembly of G-quadruplex architectures in self-organized nanohybrids. In the first resolution step the G-quartet is pre-amplified in solution in the presence of metal cations from a dynamic pool of ribbon-type or cyclic supramolecular architectures. Then in a second selection sol-gel step the G-quadruplex is irreversibly fixed in a siloxane inorganic network. The interface between the guanosine moiety and the heterosiloxane 3 is based on a double reversible covalent iminoboronate connection. This contributes to the high levels of adaptability and correlation in the self-organization of the supramolecular G-quadruplex and the inorganic siloxane systems. Biomimetic-type hybrids can be generated by using this strategy.
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Dates et versions

hal-00587204 , version 1 (19-04-2011)

Identifiants

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Simona Mihai, Yann Le Duc, Didier Cot, Mihai Barboiu. Sol-gel selection of hybrid G-quadruplex architectures from dynamic supramolecular guanosine libraries. Journal of Materials Chemistry, 2010, 20, pp.9443-9448. ⟨10.1039/c0jm01248c⟩. ⟨hal-00587204⟩
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