Anti-social cells: Predicting the influence of E-cadherin loss on the growth of epithelial cell populations
Résumé
The characteristics of biological tissues are determined by the interactions of large numbers of autonomous cells. These interactions can be mediated remotely by diffusive biochemical factors, or by direct cell-cell contact. E-cadherin is a protein expressed on the surface of normal epithelial cells that plays a key role in mediating intercellular adhesion via calcium-dependent homotypic interactions. E-cadherin is a metastasis-suppressor protein and its loss of function is associated with malignant progression.
Origine : Fichiers produits par l'(les) auteur(s)
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