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Article Dans Une Revue Analytical and Bioanalytical Chemistry Année : 2010

Contribution of microextraction in packed sorbent for the analysis of cotinine in human urine by GC-MS.

Résumé

A simple, rapid, sensitive, and non-consuming solvent method for the determination of cotinine in urine was developed, based on sample preparation by the relatively new technique microextraction in packed sorbent (MEPS) and analysis by GC-MS. This optimized method was compared with conventional solid-phase extraction/liquid-liquid extraction method used as reference. The wide linear range (5-5,000 ng/mL) and high sensitivity of the MEPS method (limit of detection 0.8 ng/mL) allow application to analysis of urine from smokers as well as non-smokers susceptible to passive smoking.

Dates et versions

hal-00509161 , version 1 (10-08-2010)

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Citer

Florent Lafay, Emmanuelle Vulliet, Marie-Magdeleine Flament-Waton. Contribution of microextraction in packed sorbent for the analysis of cotinine in human urine by GC-MS.. Analytical and Bioanalytical Chemistry, 2010, 396 (2), pp.937-941. ⟨10.1007/s00216-009-3236-4⟩. ⟨hal-00509161⟩

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