This study investigates an optimization-based heuristic for the Robotic Cell Problem. This problem arises in automated cells and is a complex ‡ow shop problem with a single transportation robot and a blocking constraint. We propose an approximate decomposition algorithm. The proposed approach breaks the problem into two scheduling problems that are solved sequentially: a flow shop problem with additional constraints (blocking and transportation times) and a single machine problem with precedence constraints, time lags, and setup times. For each of these problems, we propose an exact branch-and-bound algorithm. Also, we describe a genetic algorithm that includes, as a mutation operator, a local search procedure. We report the results of a computational study that provides evidence that the proposed optimization-based approach delivers high-quality solutions and consistently outperforms the genetic algorithm. However, the genetic algorithm delivers reasonably good solutions while requiring significantly shorter CPU times.