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Article Dans Une Revue Langmuir Année : 2009

Easy Route to Functionalize Iron Oxide Nanoparticles via Long-Term Stable Thiol Groups

Résumé

The functionalization of superparamagnetic iron oxide nanoparticles (SPIOs) by meso-2,3-dimercaptosuccinic acid (DMSA) was investigated. Under ambient conditions, the thiol groups from DMSA are not stable and do not allow a direct functionalization without storage in stringent conditions or a chemical regeneration of free thiols. In this study, we have developed a protocol based on poly(ethylene glycol) (PEG) grafting of SPIO prior to DMSA anchoring. We have observed that PEG helps to increase the stability of thiol groups under ambient conditions. The thiol functionalized SPIOs were stable under physiological pH and ionic strength as determined by Ellman's essay and allowed us to graft a thiol reactive fluorescent dye: tetramethylrhodamine-5-maleimide (TMRM).

Domaines

Matériaux
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Dates et versions

hal-00447491 , version 1 (15-03-2021)

Identifiants

Citer

L Maurizi, H Bisht, Frédéric Bouyer, Nadine Millot. Easy Route to Functionalize Iron Oxide Nanoparticles via Long-Term Stable Thiol Groups. Langmuir, 2009, 25 (16), pp.8857-8859. ⟨10.1021/la901602w⟩. ⟨hal-00447491⟩
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